[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetyl chloride

Base Information

Chemical Name:[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetyl chloride
CAS No.:75527-62-7
Molecular Formula:C₁₃H₁₅ClFNO
Molecular Weight:255.72
Hs Code.:

Synonyms:

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Chemical Property of [3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetyl chloride

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Technology Process of [3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetyl chloride

There total 10 articles about [3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75527-60-5
[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid

: 75527-62-7
[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetyl chloride

Guidance literature:: With thionyl chloride; In chloroform; at 35 ℃; for 3h;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 75527-62-7
[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetyl chloride

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) Mg / 1.) THF, reflux, 1 h 2.) THF, reflux, 20 h

2: conc. HCl / ethanol; H₂O / 50 h / Heating

3: 85 percent / benzene / 3 h / Heating

4: m-chloroperbenzoic acid / CHCl₃

5: boron trifluoride etherate / diethyl ether / 5 h / Heating

6: lithium aluminum hydride / diethyl ether / 3 h / Heating

7: 74 percent / thionyl chloride / CHCl₃ / 5 h / Heating

8: 63 percent / dimethylsulfoxide / 10 h / 130 - 140 °C

9: conc. HCl / 10 h / Heating

10: thionyl chloride / CHCl₃ / 3 h / 35 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; boron trifluoride diethyl etherate; magnesium; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol; chloroform; water; dimethyl sulfoxide; benzene;

Reference yield:

: 1073-06-9
3-fluorobromobenzene

: 75527-62-7
[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetyl chloride

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) Mg / 1.) THF, reflux, 1 h 2.) THF, reflux, 20 h

2: conc. HCl / ethanol; H₂O / 50 h / Heating

3: 85 percent / benzene / 3 h / Heating

4: m-chloroperbenzoic acid / CHCl₃

5: boron trifluoride etherate / diethyl ether / 5 h / Heating

6: lithium aluminum hydride / diethyl ether / 3 h / Heating

7: 74 percent / thionyl chloride / CHCl₃ / 5 h / Heating

8: 63 percent / dimethylsulfoxide / 10 h / 130 - 140 °C

9: conc. HCl / 10 h / Heating

10: thionyl chloride / CHCl₃ / 3 h / 35 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; boron trifluoride diethyl etherate; magnesium; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol; chloroform; water; dimethyl sulfoxide; benzene;