[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid

Base Information

Chemical Name:[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid
CAS No.:75527-60-5
Molecular Formula:C₁₃H₁₆FNO₂
Molecular Weight:237.274
Hs Code.:

Synonyms:

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Chemical Property of [3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid

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Technology Process of [3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid

There total 10 articles about [3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 75527-60-5
[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) Mg / 1.) THF, reflux, 1 h 2.) THF, reflux, 20 h

2: conc. HCl / ethanol; H₂O / 50 h / Heating

3: 85 percent / benzene / 3 h / Heating

4: m-chloroperbenzoic acid / CHCl₃

5: boron trifluoride etherate / diethyl ether / 5 h / Heating

6: lithium aluminum hydride / diethyl ether / 3 h / Heating

7: 74 percent / thionyl chloride / CHCl₃ / 5 h / Heating

8: 63 percent / dimethylsulfoxide / 10 h / 130 - 140 °C

9: conc. HCl / 10 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; boron trifluoride diethyl etherate; magnesium; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol; chloroform; water; dimethyl sulfoxide; benzene;

Reference yield:

: 1073-06-9
3-fluorobromobenzene

: 75527-60-5
[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) Mg / 1.) THF, reflux, 1 h 2.) THF, reflux, 20 h

2: conc. HCl / ethanol; H₂O / 50 h / Heating

3: 85 percent / benzene / 3 h / Heating

4: m-chloroperbenzoic acid / CHCl₃

5: boron trifluoride etherate / diethyl ether / 5 h / Heating

6: lithium aluminum hydride / diethyl ether / 3 h / Heating

7: 74 percent / thionyl chloride / CHCl₃ / 5 h / Heating

8: 63 percent / dimethylsulfoxide / 10 h / 130 - 140 °C

9: conc. HCl / 10 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; boron trifluoride diethyl etherate; magnesium; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol; chloroform; water; dimethyl sulfoxide; benzene;

Reference yield:

: 75527-56-9
1-methyl-3-chloromethyl-3-(m-fluorophenyl)pyrrolidine

: 75527-60-5
[3-(3-Fluoro-phenyl)-1-methyl-pyrrolidin-3-yl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / dimethylsulfoxide / 10 h / 130 - 140 °C

2: conc. HCl / 10 h / Heating

With hydrogenchloride; In dimethyl sulfoxide;