phenylmethyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate

Base Information

Chemical Name:phenylmethyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate
CAS No.:109639-07-8
Molecular Formula:C₂₇H₃₈N₃O₆P
Molecular Weight:531.589
Hs Code.:

phenylmethyl N-<<amino<1-<N-<(phenylmethoxy)carbonyl>amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate

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Chemical Property of phenylmethyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate

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Technology Process of phenylmethyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate

There total 8 articles about phenylmethyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₆ClN₂O₆P

: 109639-07-8,109717-04-6,109717-05-7,109717-06-8
phenylmethyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate

Guidance literature:: With ammonia; In dichloromethane; Yield given; 1.) -33 deg C, 1 h, 2.) 22 deg C, 1.5 h;
DOI:10.1021/jm00392a014

Reference yield:

: 109638-99-5
(+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid

: 109639-07-8,109717-04-6,109717-05-7,109717-06-8
phenylmethyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / methanol; diethyl ether / 0.5 h / 22 °C

2: Et₃N / CH₂Cl₂ / 0.5 h

3: Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

4: Me₃SiBr / CH₂Cl₂; various solvent(s) / 5 h / 22 °C

5: SOCl₂ / CH₂Cl₂ / 0.25 h / 22 °C

6: NH₃ / CH₂Cl₂ / 1.) -33 deg C, 1 h, 2.) 22 deg C, 1.5 h

With thionyl chloride; trimethylsilyl bromide; ammonia; triethylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00392a014

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 109639-07-8,109717-04-6,109717-05-7,109717-06-8
phenylmethyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / 2.0 M aq. NaOH, NaHCO₃, Na₂CO₃ / 22 °C

2: 100 percent / methanol; diethyl ether / 0.5 h / 22 °C

3: Et₃N / CH₂Cl₂ / 0.5 h

4: Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

5: Me₃SiBr / CH₂Cl₂; various solvent(s) / 5 h / 22 °C

6: SOCl₂ / CH₂Cl₂ / 0.25 h / 22 °C

7: NH₃ / CH₂Cl₂ / 1.) -33 deg C, 1 h, 2.) 22 deg C, 1.5 h

With sodium hydroxide; thionyl chloride; trimethylsilyl bromide; ammonia; sodium hydrogencarbonate; sodium carbonate; triethylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00392a014