N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine

Base Information

Chemical Name:N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine
CAS No.:89637-86-5
Molecular Formula:C₃₂H₄₆N₁₂O₇
Molecular Weight:710.793
Hs Code.:

N<sup>ε</sup>-<N-(4-amino-4-deoxy-N<sup>10</sup>-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine

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Technology Process of N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine

There total 9 articles about N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 89637-92-3
N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)L-glutamyl>-γ-L-lysyl-N'-(benzyloxycarbonyl)-L-lysine

: 89637-86-5
N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine

Guidance literature:: With hydrogen bromide; acetic acid; for 1h; Ambient temperature;
DOI:10.1021/jm00373a014

Reference yield:

: 13030-09-6
1-benzyl L-glutamate

: 89637-86-5
N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / Et₃N / benzene / Ambient temperature

2: 1.) diethyl phosphorocyanidate, Et₃N / 1.) DMF, overnight, RT, 2.) DMF, RT, 3 d

3: Et₃N / dimethylformamide / 0.33 h / Ambient temperature

4: dimethylformamide / Ambient temperature

5: 79 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 0 - 20 °C

6: 86 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

7: 42 percent / AcOH, HBr / 1 h / Ambient temperature

With barium dihydroxide; diethyl cyanophosphonate; diphenylphosphoranyl azide; hydrogen bromide; acetic acid; triethylamine; In ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00373a014

Reference yield:

: 13734-28-6
Boc-Lys-OH

: 89637-86-5
N^ε-10-methylpteroyl)-L-glutamyl>-γ-L-lysyl-L-lysine

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Et₃N / benzene / Ambient temperature

2: dimethylformamide / Ambient temperature

3: 79 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 0 - 20 °C

4: 86 percent / Ba(OH)2*8H₂O / ethanol; H₂O / Ambient temperature

5: 42 percent / AcOH, HBr / 1 h / Ambient temperature

With barium dihydroxide; diphenylphosphoranyl azide; hydrogen bromide; acetic acid; triethylamine; In ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00373a014