Heptanoic acid, 7-[3-[(hydroxyphosphinyl)oxy]-2-(phenylmethoxy)propoxy]-, phenylmethyl ester, (R)-, compd. with N,N-diethylethanamine (1:1)

Base Information

• Chemical Name: Heptanoic acid, 7-[3-[(hydroxyphosphinyl)oxy]-2-(phenylmethoxy)propoxy]-, phenylmethyl ester, (R)-, compd. with N,N-diethylethanamine (1:1)
• CAS No.: 139141-25-6
• Molecular Formula: C₆H₁₅N*C₂₄H₃₃O₇P
• Molecular Weight: 565.687
• Mol file: 139141-25-6.mol

Synonyms:

Chemical Property of Heptanoic acid, 7-[3-[(hydroxyphosphinyl)oxy]-2-(phenylmethoxy)propoxy]-, phenylmethyl ester, (R)-, compd. with N,N-diethylethanamine (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Heptanoic acid, 7-[3-[(hydroxyphosphinyl)oxy]-2-(phenylmethoxy)propoxy]-, phenylmethyl ester, (R)-, compd. with N,N-diethylethanamine (1:1)

There total 18 articles about Heptanoic acid, 7-[3-[(hydroxyphosphinyl)oxy]-2-(phenylmethoxy)propoxy]-, phenylmethyl ester, (R)-, compd. with N,N-diethylethanamine (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 7-bromoheptanoate (29823-18-5) → 1-O-<6-(Benzyloxycarbonyl)hexyl>-2-O-benzylglycero-3-H-phosphonic acid triethylammonium salt (139141-25-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 1) NaH / 1) DMF, rt, 2) DMF, rt

2: 1.6 M NaOH / dioxane / Ambient temperature

3: NaHCO₃ / dimethylformamide / 40 °C

4: 2 M HCl / tetrahydrofuran / Ambient temperature

5: pyridine / Ambient temperature

6: 1) NaH, 2) BuN₄I / 1) DMF, rt, 2) DMF, rt

7: 1 M HCl / dioxane / 80 °C

8: 1) imidazole, PCl₃, Et₃N / 1) MeCN, 2) MeCN, toluene, rt

With pyridine; 1H-imidazole; hydrogenchloride; sodium hydroxide; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; triethylamine; phosphorus trichloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)96051-X

Reference yield:

ethyl 7-bromoheptanoate (29823-18-5) → 1-O-<6-(Benzyloxycarbonyl)hexyl>-2-O-benzyl-sn-glycero-3H-phosphonic acid triethylammonium salt (139141-25-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 1) NaH / 1) DMF, rt, 2.5 h, 2) DMF, rt, 48 h

2: 10.4 g / 1.6 M NaOH / dioxane / 18 h / Ambient temperature

3: NaHCO₃ / dimethylformamide / 18 h / 40 °C

4: 82 percent / 2 M HCl / tetrahydrofuran / 4 h / Ambient temperature

5: 80 percent / pyridine / 17 h / Ambient temperature

6: 1) NaH, 2) BuN₄I / 1) DMF, 45 min, rt, 2) DMF, 24 h, rt

7: 55 percent / 1 M HCl / dioxane / 4 h / 80 °C

8: 1) imidazole, PCl₃, Et₃N / 1) MeCN, 15 min, 2) MeCN, toluene, rt, 4 h

With pyridine; 1H-imidazole; hydrogenchloride; sodium hydroxide; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; triethylamine; phosphorus trichloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)96051-X

Reference yield:

benzyl bromide (100-39-0) → 1-O-<6-(Benzyloxycarbonyl)hexyl>-2-O-benzyl-sn-glycero-3H-phosphonic acid triethylammonium salt (139141-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) NaH, 2) BuN₄I / 1) DMF, 45 min, rt, 2) DMF, 24 h, rt

2: 55 percent / 1 M HCl / dioxane / 4 h / 80 °C

3: 1) imidazole, PCl₃, Et₃N / 1) MeCN, 15 min, 2) MeCN, toluene, rt, 4 h

With 1H-imidazole; hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; phosphorus trichloride; In 1,4-dioxane;

DOI:10.1016/S0040-4020(01)96051-X

upstream raw materials:

1-O-<6-(Benzyloxycarbonyl)hexyl>-2-O-benzylglycerol

ethyl 7-bromoheptanoate

1-O-(6-Carboxyhexyl)-2,3-isopropylideneglycerol

1-O-(6-Ethoxycarbonylhexyl)-2,3-isopropylideneglycerol

Downstream raw materials:

1-O-(6-Carboxyhexyl)-sn-glycero-3-phosphoserine