Acetic acid 2-{2,4-bis-(tetrahydro-pyran-2-yloxy)-6-[(E)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-phenyl}-ethyl ester

Base Information

• Chemical Name: Acetic acid 2-{2,4-bis-(tetrahydro-pyran-2-yloxy)-6-[(E)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-phenyl}-ethyl ester
• CAS No.: 76697-77-3
• Molecular Formula: C₃₃H₅₀O₈
• Molecular Weight: 574.755
• Mol file: 76697-77-3.mol

Synonyms:

Chemical Property of Acetic acid 2-{2,4-bis-(tetrahydro-pyran-2-yloxy)-6-[(E)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-phenyl}-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 2-{2,4-bis-(tetrahydro-pyran-2-yloxy)-6-[(E)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-phenyl}-ethyl ester

There total 12 articles about Acetic acid 2-{2,4-bis-(tetrahydro-pyran-2-yloxy)-6-[(E)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-phenyl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromoheptan-2-one (16339-93-8) → Acetic acid 2-{2,4-bis-(tetrahydro-pyran-2-yloxy)-6-[(E)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-phenyl}-ethyl ester (76697-77-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 260 g / benzene / 72 h / Ambient temperature

2: 220 g / 1N NaOH / methanol; H₂O / 0.08 h

3: 76 g / CHCl₃ / 48 h / Heating

4: 222 g / Pyridin / diethyl ether / 1.) 0 deg C, 2 h 2.) 10 deg C, 1 h

5: 182 g / ZnCl₂, NaBH₄ / diethyl ether / 2 h / Ambient temperature

6: p-Toluolsulfonsaeure / benzene / 2 h / Ambient temperature

With pyridine; sodium hydroxide; sodium tetrahydroborate; toluene-4-sulfonic acid; zinc(II) chloride; In methanol; diethyl ether; chloroform; water; benzene;

DOI:10.1002/hlca.19800630612

Reference yield:

6-Hydroxy-2-oxo-2,3-dihydro-4-benzofurancarbonsaeure (76697-62-6) → Acetic acid 2-{2,4-bis-(tetrahydro-pyran-2-yloxy)-6-[(E)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-phenyl}-ethyl ester (76697-77-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 130 g / LiBH₄ / tetrahydrofuran / 1.) 2 h 2.) reflux, 4 h

2: 145 g / p-Toluolsulfonsaeure / benzene; tetrahydrofuran / 6 h

3: 98 g / Dibal / toluene / 2.5 h / -70 °C

4: 76 g / CHCl₃ / 48 h / Heating

5: 222 g / Pyridin / diethyl ether / 1.) 0 deg C, 2 h 2.) 10 deg C, 1 h

6: 182 g / ZnCl₂, NaBH₄ / diethyl ether / 2 h / Ambient temperature

7: p-Toluolsulfonsaeure / benzene / 2 h / Ambient temperature

With pyridine; sodium tetrahydroborate; lithium borohydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; zinc(II) chloride; In tetrahydrofuran; diethyl ether; chloroform; toluene; benzene;

DOI:10.1002/hlca.19800630612

Reference yield:

ethyl 3,5-dimethoxybenzoate (17275-82-0) → Acetic acid 2-{2,4-bis-(tetrahydro-pyran-2-yloxy)-6-[(E)-3-(tetrahydro-pyran-2-yloxy)-oct-1-enyl]-phenyl}-ethyl ester (76697-77-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 98 percent / 90percent H₂SO₄ / 4 h

2: 149 g / red phosphor, 57percent HI / 5 h / Heating

3: 130 g / LiBH₄ / tetrahydrofuran / 1.) 2 h 2.) reflux, 4 h

4: 145 g / p-Toluolsulfonsaeure / benzene; tetrahydrofuran / 6 h

5: 98 g / Dibal / toluene / 2.5 h / -70 °C

6: 76 g / CHCl₃ / 48 h / Heating

7: 222 g / Pyridin / diethyl ether / 1.) 0 deg C, 2 h 2.) 10 deg C, 1 h

8: 182 g / ZnCl₂, NaBH₄ / diethyl ether / 2 h / Ambient temperature

9: p-Toluolsulfonsaeure / benzene / 2 h / Ambient temperature

With pyridine; phosphorus; sodium tetrahydroborate; lithium borohydride; sulfuric acid; hydrogen iodide; diisobutylaluminium hydride; toluene-4-sulfonic acid; zinc(II) chloride; In tetrahydrofuran; diethyl ether; chloroform; toluene; benzene;

DOI:10.1002/hlca.19800630612

upstream raw materials:

1-bromoheptan-2-one

6-Hydroxy-2-oxo-2,3-dihydro-4-benzofurancarbonsaeure

ethyl 3,5-dimethoxybenzoate

4,6-dimethoxy-3-trichloromethyl-1-benzo[c]furanone

Downstream raw materials:

2-<2,4-Bis((tetrahydropyran-2-yl)oxy)-6-(3-((tetrahydropyran-2-yl)oxy)-1-octenyl)-phenyl>aethanol