17275-82-0

Usage

InChI:InChI=1/C11H14O4/c1-4-15-11(12)8-5-9(13-2)7-10(6-8)14-3/h5-7H,4H2,1-3H3

Upstream product

• 64-17-5 ethanol 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 4142-98-7 ethyl 3,5-dihydroxybenzoate 
• 77-78-1 dimethyl sulfate 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 60-29-7 diethyl ether 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 95-92-1 oxalic acid diethyl ester 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 6148-64-7 ethyl potassium malonate 
• 108-46-3 recorcinol 
• 71-43-2 benzene 
• 99-10-5 3,5-Dihydroxybenzoic acid 

Downstream Products

• 17275-83-1 3,5-dimethoxy-2-nitro-benzoic acid ethyl ester 
• 51707-38-1 3,5-dimethoxy-benzoic acid hydrazide 
• 877-88-3 3,5-dimethoxybenzyl bromide 
• 705-76-0 3,5-dimethoxybenzyl alcohol 
• 77376-80-8 α-methylsulphinyl-3,5-dimethoxyacetophenone 
• 5859-84-7 2-chloro-3,5-dimethoxybenzyl alcohol 
• 75177-61-6 2-chloro-3,5-dimethoxybenzyl chloride 
• 75177-60-5 2,6-dichloro-3,5-dimethoxybenzyl alcohol 
• 75177-67-2 3-(2-chloro-3,5-dimethoxybenzyl)propionic acid 
• 75177-66-1 2-chloro-3,5-dimethoxybenzylmalonic acid 
• 75177-63-8 diethyl (2-chloro-3,5-dimethoxybenzyl)malonate 
• 75177-64-9 diethyl (2,6-dichloro-3,5-dimethoxybenzyl)malonate 
• 75177-65-0 diethyl bis(2-chloro-3,5-dimethoxybenzyl)malonate 
• 387372-17-0 Resveratrol-3-O-glucuronide 

Relevant academic research and scientific papers

Nickel-Catalyzed Esterification of Amides Under Mild Conditions

Abstract: The use of ligands to adjust the catalytic activity of the catalyst for esterification of amides is challenge in organic chemistry. In this paper, Nickel(II)-NHC-catalyzed the esterification reaction between N,N-di-Boc amide and alcohols at room temperature have been demonstrated. The imidazolium salt bearing a hydroxyl functionalized side arm showed high effective catalytic activity in the activation of the amide N–C bond in air atmosphere. Graphic Abstract: [Figure not available: see fulltext.].

New composition for improving skin conditions

The present invention relates to a composition for improving skin condition which comprises a derivative of a compound represented by chemical formula (I) or a pharmacologically acceptable salt thereof. In the chemical formula (I), X is hydrogen or methoxy, and R is a C1 to C20 linear or branched alkyl group.COPYRIGHT KIPO 2020

Facile, highly efficient and environmentally friendly transesterification mediated by platinum dioxide and nickel oxide under essentially neutral conditions

A practical, facile and highly efficient transesterification reaction under essentially neutral conditions was achieved using platinum dioxide (PtO2) or PtO2/nickel oxide (NiO) as the catalyst. A number of esters and alcohols that contain various functional groups were employed. Good to excellent yields were obtained for different aromatic or aliphatic starting materials. The Pt-alcohol intermediate generated in situ facilitated the exchange of low-alcohol esters to high-alcohol esters.

Design, synthesis, biological evaluation, and 3D-QSAR analysis of podophyllotoxin–dioxazole combination as tubulin targeting anticancer agents

The advancement of cancer-fighting drugs has never been a simple linear process. Those drug design professionals begin to find inspiration from the nature after failing to find the ideal products by creative drug design and high-throughput screening. To obtain new molecules for inhibiting tubulin, podophyllotoxin was adopted as the leading compound and 1,3,4-oxadiazole was brought in to the C-4 site of podophyllotoxin in this research. A series of seventeen podophyllotoxin-derived esters have been achieved and then evaluated their antitumor activities against four different cancer cell lines: A549, MCF-7, HepG2, and HeLa. Among all the compounds, compound 7c showed the best antiproliferating properties with IC50?=?2.54?±?0.82?μm against MCF-7 cancer cell line. It was obvious that the content of ROS grew significantly in MCF-7 in a way depending on the dosage. The time- and dose-dependent cell cycle assays revealed that compound 7c could apparently block cell cycle in the phase of G2/M along with the upregulation of cyclin A2 and CDK2 protein. According to further studies, confocal microscopy experiment has certified that compound 7c could restrain cancer from growing by blocking the polymerization of microtubule. Meanwhile, compound 7c could be ideally integrated with the colchicine site of tubulin. In future, it would be feasible to selectively design tubulin inhibitors with the help of 3D-QSAR. This means that it is hopeful to develop compound 7c as a potential agent against cancer due to its biological characteristics.

Diethyloxalate as “CO” Source for Palladium-Catalyzed Ethoxycarbonylation of Bromo- and Chloroarene Derivatives

Palladium(II)-catalyzed ethoxycarbonylation of aryl bromides with diethyloxalate oxalate is described. Functionalized aromatic esters can be efficiently synthesized with only 0.65 mol % PdCl2(PPh3)2 catalyst under microwav

Design, Synthesis and Anti-Proliferative Activities of 2,6-Substituted Thieno[3,2-d]pyrimidine Derivatives Containing ElectrophilicWarheads

Thieno[3,2-d]pyrimidine as an effective pharmacophore has been extensively studied. However, its 2,6-substituted derivatives are rarely reported. In the present study, eighteen 2,6-substituted thieno[3,2-d]pyrimidine derivatives containing electrophilic warheads were designed based on the first known Fibroblast growth factor receptor-4 (FGFR4) inhibitor Blu9931. Unexpectedly, all of the derivatives exhibited negligible activity against FGFR4. However, most of the target compounds exhibited antiproliferative activities against four human cancer cell lines, including A431, NCI-H1975, Ramos and SNU-16. Compound 12 showed the most potent antiproliferative activities on the above four cell lines with IC50 values of 1.4 μM, 1.2 μM, 0.6 μM, and 2.6 μM, respectively. Additionally, the antiproliferative activity of 12 against MDA-MB-221 proved that 12 had the selectivity towards certain tumor cell lines. Furthermore, preliminary structure-Activity relationship analysis was discussed based on the experimental data.

Synthesis method of 3,5-dimethoxybenzoic acid ethyl ester

The invention discloses a synthesis method of 3,5-dimethoxybenzoic acid ethyl ester, and belongs to the field of chemosynthesis. According to the method, benzene is firstly used for producing resorcinol under specific conditions; under the condition of using dimethylformamide as a solvent by anhydrous potassium carbonate and carbon dioxide, the 3,5-dihydroxy-benzoic acid is finally obtained through impurity removal, decoloring, pH value regulation and cooling crystallization; then, the 3,5-dihydroxy-benzoic acid is mixed with dimethyl sulfate in a stirring condition; a sodium hydroxide solution is dropwise added into the materials for backflow; the pH value is regulated after the backflow; the pressure reduction filtering, washing and drying are carried out after cooling to 0 DEG C; the 3,5-dimethoxybenzoic acid is obtained; finally, the 3,5-dimethoxybenzoic acid is esterified with absolute ethyl alcohol under the condition of concentrated sulfuric acid; finally, the 3,5-dimethoxybenzoic acid ethyl ester is obtained.

Metal-free aerobic oxidative esterification of aldehydes in the presence of cyanide

A metal-free aerobic oxidative esterification of aldehydes in the presence of cyanide is described. Various aromatic aldehydes and sterically congested alcohols were amenable to this protocol. In addition, this method could be extended to the preparation of thioesters with a thiol in place of an alcohol. Furthermore, the cyanide-mediated aerobic oxidation of aldehydes was applied to the synthesis of lactones via intramolecular esterification in the absence of an alcohol.

Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents

A series of novel 1,3,4-oxadiazole thioether derivatives (compounds 9-44) were designed and synthesized as potential inhibitors of thymidylate synthase (TS) and as anticancer agents. The in vitro anticancer activities of these compounds were evaluated against three cancer cell lines by the MTT method. Among all the designed compounds, compound 18 bearing a nitro substituent exhibited more potent in vitro anticancer activities with IC50 values of 0.7 ± 0.2, 30.0 ± 1.2, 18.3 ± 1.4 μM, respectively, which was superior to the positive control. In the further study, it was identified as the most potent inhibitor against two kinds of TS protein (for human TS and Escherichia coli TS, IC50 values: 0.62 and 0.47 μM, respectively) in the TS inhibition assay in vitro and the most potent antibacterial agents with MIC (minimum inhibitory concentrations) of 1.56-3.13 μg/mL against the tested four bacterial strains. Molecular docking and 3D-QSAR study supported that compound 18 can be selected as dual antitumor/antibacterial candidate in the future study.

Practical preparation of resveratrol 3-O-β-D-glucuronide

A practical synthesis of resveratrol 3-Oβl-D-glucuronide, suitable for preparation of large quantities, was developed using selective deacetylation of resveratrol triacetate with ammonium acetate. A simplified procedure for large-scale preparation of resveratrol is also reported.