1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Base Information

Chemical Name:1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole
CAS No.:137016-77-4
Molecular Formula:C₄₈H₆₇Cl₆N₄O₁₀PSi₃
Molecular Weight:1188.03
Hs Code.:

1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-<O<sup>P</sup>-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

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Chemical Property of 1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

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Technology Process of 1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

There total 12 articles about 1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 137016-75-2,137120-02-6
1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

: 137016-77-4,137119-96-1
1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Guidance literature:: With toluene-4-sulfonic acid; In methanol; dichloromethane; for 6h; Ambient temperature;
DOI:10.1016/0008-6215(92)84178-U

Reference yield:

: 6478-73-5
5,6-dichlorobenzimidazole

: 137016-77-4,137119-96-1
1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Guidance literature:: Multi-step reaction with 7 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 35 percent / pyridine / 18 h / Ambient temperature

6: 57 percent / N-methylimidazole, 2,4,6-tri-isopropylbenzenesulfonyl chloride / pyridine / 20 h / Ambient temperature

7: 95 percent / p-TsOH / CH₂Cl₂; methanol / 6 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; sodium methylate; toluene-4-sulfonic acid; In pyridine; methanol; dichloromethane;
DOI:10.1016/0008-6215(92)84178-U

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 137016-77-4,137119-96-1
1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-(2,5-dichlorophenyl)>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Guidance literature:: Multi-step reaction with 7 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 35 percent / pyridine / 18 h / Ambient temperature

6: 57 percent / N-methylimidazole, 2,4,6-tri-isopropylbenzenesulfonyl chloride / pyridine / 20 h / Ambient temperature

7: 95 percent / p-TsOH / CH₂Cl₂; methanol / 6 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; sodium methylate; toluene-4-sulfonic acid; In pyridine; methanol; dichloromethane;
DOI:10.1016/0008-6215(92)84178-U