Technology Process of methyl(2R,3S)-2-((tert-butyloxycarbonyl)amino)-3-mercapto-3-phenylpropionate
There total 10 articles about methyl(2R,3S)-2-((tert-butyloxycarbonyl)amino)-3-mercapto-3-phenylpropionate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
2: H2O2, HCOOH
3: 1) 2N aq. LiOH / 1) dioxane, RT, overnight, 2a) Et2O, 0 deg C, 15 min, 2b) RT, 30 min
4: NEt3 / CH2Cl2 / 0.75 h / 0 °C
5: 87 percent / DBU, thiolacetic acid / dimethylformamide / 30 h / Ambient temperature
6: NaOH / 0.5 h
With
lithium hydroxide; sodium hydroxide; formic acid; dihydrogen peroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tiolacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00038a048
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1) Sn(OTf)2, NEt3
4: H2O2, HCOOH
5: 1) 2N aq. LiOH / 1) dioxane, RT, overnight, 2a) Et2O, 0 deg C, 15 min, 2b) RT, 30 min
6: NEt3 / CH2Cl2 / 0.75 h / 0 °C
7: 87 percent / DBU, thiolacetic acid / dimethylformamide / 30 h / Ambient temperature
8: NaOH / 0.5 h
With
lithium hydroxide; sodium hydroxide; tin(II) trifluoromethanesulfonate; formic acid; dihydrogen peroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tiolacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00038a048
