Technology Process of 3a-cyclopropyl-2-methoxycarbonyl-4-oxo-2-phenyl-4H-2,3,3a,11c-tetrahydropyrro<1,3-d>naphtho<2,1-b>pyran
There total 17 articles about 3a-cyclopropyl-2-methoxycarbonyl-4-oxo-2-phenyl-4H-2,3,3a,11c-tetrahydropyrro<1,3-d>naphtho<2,1-b>pyran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-butyl lithium / 1.) 4 h, r.t., ether, hexan; 2.) ether, r.t., 15 h
2: 69 percent / sodium hydroxide / H2O; ethanol / 3 h / Heating
3: 1.) dicyclohexylcarbodiimide, p-toluenesulphonic acid; 2.) g. acetic acid / 1.) pyridine, 24 h; 2.) 2 h, r.t., 0 degC, overnight
4: 95 percent / sodium sulphate / CH2Cl2 / reflux 1 h, r.t. 10 h
5: xylene / 24 h / Heating
With
sodium hydroxide; n-butyllithium; toluene-4-sulfonic acid; acetic acid; sodium sulfate; dicyclohexyl-carbodiimide;
In
ethanol; dichloromethane; water; xylene;
DOI:10.1016/S0040-4020(01)85931-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) dicyclohexylcarbodiimide, p-toluenesulphonic acid; 2.) g. acetic acid / 1.) pyridine, 24 h; 2.) 2 h, r.t., 0 degC, overnight
2: 95 percent / sodium sulphate / CH2Cl2 / reflux 1 h, r.t. 10 h
3: xylene / 24 h / Heating
With
toluene-4-sulfonic acid; acetic acid; sodium sulfate; dicyclohexyl-carbodiimide;
In
dichloromethane; xylene;
DOI:10.1016/S0040-4020(01)85931-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 69 percent / sodium hydroxide / H2O; ethanol / 3 h / Heating
2: 1.) dicyclohexylcarbodiimide, p-toluenesulphonic acid; 2.) g. acetic acid / 1.) pyridine, 24 h; 2.) 2 h, r.t., 0 degC, overnight
3: 95 percent / sodium sulphate / CH2Cl2 / reflux 1 h, r.t. 10 h
4: xylene / 24 h / Heating
With
sodium hydroxide; toluene-4-sulfonic acid; acetic acid; sodium sulfate; dicyclohexyl-carbodiimide;
In
ethanol; dichloromethane; water; xylene;
DOI:10.1016/S0040-4020(01)85931-7
