2-[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide

Base Information

Chemical Name:2-[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide
CAS No.:221302-07-4
Molecular Formula:C₄₂H₄₅N₅O₁₁
Molecular Weight:795.846
Hs Code.:

2-[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide

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Chemical Property of 2-[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide

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Technology Process of 2-[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide

There total 5 articles about 2-[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 221302-07-4
2-[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / pyridine / CH₂Cl₂ / 1 h

2: 67 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

3: 88 percent / Bu₃SnH, AIBN / toluene / 8 h / 65 °C

4: 67 percent / H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 4 h

5: 1.) 1,3-dicyclohexylcarbodiimide, DMAP, N-hydroxysuccinimide, 2.) pyridine / 1.) dioxane, overnight, 2.) dioxane, 2.5 h

With pyridine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1039/a808505f

Reference yield:

: 185141-87-1
[(2R,3R,4S,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

: 221302-07-4
2-[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / pyridine / CH₂Cl₂ / 1 h

2: 67 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

3: 88 percent / Bu₃SnH, AIBN / toluene / 8 h / 65 °C

4: 67 percent / H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 4 h

5: 1.) 1,3-dicyclohexylcarbodiimide, DMAP, N-hydroxysuccinimide, 2.) pyridine / 1.) dioxane, overnight, 2.) dioxane, 2.5 h

With pyridine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1039/a808505f

Reference yield:

: 185141-90-6
[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

: 221302-07-4
2-[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

2: 88 percent / Bu₃SnH, AIBN / toluene / 8 h / 65 °C

3: 67 percent / H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 4 h

4: 1.) 1,3-dicyclohexylcarbodiimide, DMAP, N-hydroxysuccinimide, 2.) pyridine / 1.) dioxane, overnight, 2.) dioxane, 2.5 h

With pyridine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1039/a808505f