(R)-9-(2-hydroxypropyl)-N²-benzoylguanine

Base Information

• Chemical Name: (R)-9-(2-hydroxypropyl)-N²-benzoylguanine
• CAS No.: 160616-45-5
• Molecular Formula: C₁₅H₁₅N₅O₃
• Molecular Weight: 313.316
• Mol file: 160616-45-5.mol

Synonyms:

Chemical Property of (R)-9-(2-hydroxypropyl)-N²-benzoylguanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-9-(2-hydroxypropyl)-N²-benzoylguanine

There total 2 articles about (R)-9-(2-hydroxypropyl)-N²-benzoylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-9-<2-(2-tetrahydropyranyloxy)propyl>2-amino-6-chloropurine (160616-38-6) → (R)-9-(2-hydroxypropyl)-N2-benzoylguanine (160616-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / aq. HCl / 1 h / Heating

2: 1.) chlorotrimethylsilane / 1) pyridine, room temperature; 2) pyridine, room temperature

With hydrogenchloride; chloro-trimethyl-silane;

DOI:10.1135/cccc19951196

Reference yield:

benzoyl chloride (98-88-4) + (R)-9-(2-hydroxypropyl)guanine (160616-37-5) → (R)-9-(2-hydroxypropyl)-N2-benzoylguanine (160616-45-5)

Guidance literature:

With chloro-trimethyl-silane; Yield given. Multistep reaction; 1) pyridine, room temperature; 2) pyridine, room temperature;

DOI:10.1135/cccc19951196

Reference yield:

(R)-9-(2-hydroxypropyl)-N2-benzoylguanine (160616-45-5) → (R)-9-(2-phosphonomethoxypropyl)guanine (138247-60-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / dimethylformamide / 24 h / Ambient temperature

2: methanol / Ambient temperature

3: bromotrimethylsilane / acetonitrile / Ambient temperature

With methanol; trimethylsilyl bromide; sodium hydride; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1135/cccc19951196

upstream raw materials:

benzoyl chloride

(R)-9-(2-hydroxypropyl)guanine

(R)-9-<2-(2-tetrahydropyranyloxy)propyl>2-amino-6-chloropurine

Downstream raw materials:

[(R)-2-(2-Benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropyl ester

(R)-9-(2-phosphonomethoxypropyl)guanine