Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester
CAS No.:136834-42-9
Molecular Formula:C₃₆H₄₆N₈O₉
Molecular Weight:734.809
Hs Code.:

Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester

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Chemical Property of Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester

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Technology Process of Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester

There total 6 articles about Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38925-80-3
2,6-Dichloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-purine

: 136834-42-9
Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / Heating

2: H₂ / Pd/C / ethanol

3: various solvent(s) / 90 °C

4: pyridine, TEA

5: Ph₃P, DEAD / dioxane

With pyridine; TEA; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In 1,4-dioxane; ethanol;
DOI:10.1016/S0040-4039(00)76514-2

Reference yield:

: 136834-37-2
2-Chloro-6-allyloxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine

: 136834-42-9
Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethanol

2: various solvent(s) / 90 °C

3: pyridine, TEA

4: Ph₃P, DEAD / dioxane

With pyridine; TEA; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In 1,4-dioxane; ethanol;
DOI:10.1016/S0040-4039(00)76514-2

Reference yield:

: 5036-48-6
3-(1H-imidazol-1-yl)propan-1-amine

: 136834-42-9
Isobutyric acid (2R,3S,5R)-5-{2-[(3-imidazol-1-yl-propyl)-isobutyryl-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-isobutyryloxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: various solvent(s) / 90 °C

2: pyridine, TEA

3: Ph₃P, DEAD / dioxane

With pyridine; TEA; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane;
DOI:10.1016/S0040-4039(00)76514-2