Technology Process of (Z)-(5R,6R,7S,9S,16R,18S,19S)-16,18-Bis-benzyloxy-19-dibenzylamino-5,9-dimethyl-icos-11-ene-6,7-diol
There total 26 articles about (Z)-(5R,6R,7S,9S,16R,18S,19S)-16,18-Bis-benzyloxy-19-dibenzylamino-5,9-dimethyl-icos-11-ene-6,7-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: NaH, TBAI
2: 1.) O3, 2.) Me2S
3: NaH
4: H2 / Lindlar catalyst
5: CH2Cl2
6: K2CO3
7: DIBAL
8: I2, PPh3, imidazole
9: acetonitrile / Heating
10: 1.) n-BuLi
11: aq. TFA
With
1H-imidazole; n-butyllithium; dimethylsulfide; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; ozone; triphenylphosphine; trifluoroacetic acid;
Lindlar's catalyst;
In
dichloromethane; acetonitrile;
DOI:10.1021/jo9711347
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 1.) BuLi
2: K2OsO4*2H2O
3: 1.) Pb(OAc)4, 2.) NaBH4
4: Na/Liq. NH3
5: 1.) (COCl)2, DMSO, Et3N, 2.) NaClO2
6: 84 percent / I2 / acetonitrile / -30 °C
7: 1.) BnONa, 2.) H2, p-TsOH, 3.) LiAlH4 / 2.) Pd/C
8: p-TsOH
9: (COCl)2, DMSO, Et3N
10: 1.) n-BuLi
11: aq. TFA
With
lead(IV) acetate; sodium chlorite; sodium tetrahydroborate; potassium osmate(VI); lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; ammonia; hydrogen; iodine; sodium; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; sodium phenyl-methanolate; trifluoroacetic acid;
palladium on activated charcoal;
In
acetonitrile;
DOI:10.1021/jo9711347
- Guidance literature:
-
Multi-step reaction with 13 steps
2: p-TsOH / methanol
3: NaH, TBAI
4: 1.) O3, 2.) Me2S
5: NaH
6: H2 / Lindlar catalyst
7: CH2Cl2
8: K2CO3
9: DIBAL
10: I2, PPh3, imidazole
11: acetonitrile / Heating
12: 1.) n-BuLi
13: aq. TFA
With
1H-imidazole; n-butyllithium; dimethylsulfide; hydrogen; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; triphenylphosphine; trifluoroacetic acid;
Lindlar's catalyst;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo9711347
