2-(2-thiazolyl)-4-trifluoromethyl-1H-imidazole

Base Information

• Chemical Name: 2-(2-thiazolyl)-4-trifluoromethyl-1H-imidazole
• CAS No.: 279250-86-1
• Molecular Formula: C₇H₄F₃N₃S
• Molecular Weight: 219.19
• Mol file: 279250-86-1.mol

Synonyms:

Chemical Property of 2-(2-thiazolyl)-4-trifluoromethyl-1H-imidazole

Chemical Property:

Purity/Quality:

2-(4-Trifluoromethyl-1H-imidazol-2-yl)-thiazole 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-thiazolyl)-4-trifluoromethyl-1H-imidazole

There total 1 articles about 2-(2-thiazolyl)-4-trifluoromethyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

Thiazole-2-carbaldehyde (10200-59-6) + 1,1-dibromo-3,3,3-trifluoroacetone (431-67-4) → 2-(2-thiazolyl)-4-trifluoromethyl-1H-imidazole (279250-86-1)

Guidance literature:

1,1-dibromo-3,3,3-trifluoroacetone; With sodium acetate; for 0.5h; Heating;

Thiazole-2-carbaldehyde; With ammonium hydroxide; In methanol; at 20 ℃; for 20h;

DOI:10.1021/jm991154w

Reference yield: 76.0%

2-(2-thiazolyl)-4-trifluoromethyl-1H-imidazole (279250-86-1) → 2-(2-thiazolyl)-4-cyano-1H-imidazole (279250-90-7)

Guidance literature:

With ammonium hydroxide; In methanol; at 60 ℃; for 24h;

DOI:10.1021/jm991154w

Reference yield:

2-(2-thiazolyl)-4-trifluoromethyl-1H-imidazole (279250-86-1) → 2-thiazol-2-yl-1H-imidazole-4-carbaldehyde (279251-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / aq. NH₃ / methanol / 24 h / 60 °C

2: 45 percent / DIBALH / tetrahydrofuran; toluene / -78 - 0 °C

With ammonium hydroxide; diisobutylaluminium hydride; In tetrahydrofuran; methanol; toluene; 1: Substitution / 2: Reduction;

DOI:10.1021/jm991154w

upstream raw materials:

Thiazole-2-carbaldehyde

1,1-dibromo-3,3,3-trifluoroacetone

Downstream raw materials:

2-(2-thiazolyl)-4-cyano-1H-imidazole

2-thiazol-2-yl-1H-imidazole-4-carbaldehyde