4-Thiazolecarboxylic acid, 2-methyl-5-phenyl-, hydrazide

Base Information

• Chemical Name: 4-Thiazolecarboxylic acid, 2-methyl-5-phenyl-, hydrazide
• CAS No.: 139156-69-7
• Molecular Formula: C11H11N3OS
• Molecular Weight: 233.29000
• Mol file: 139156-69-7.mol

Synonyms:2-Methyl-5-phenyl-thiazole-4-carboxylic acid hydrazide;

Chemical Property of 4-Thiazolecarboxylic acid, 2-methyl-5-phenyl-, hydrazide

Chemical Property:

• PSA: 96.25000
• LogP: 2.81320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Thiazolecarboxylic acid, 2-methyl-5-phenyl-, hydrazide

There total 2 articles about 4-Thiazolecarboxylic acid, 2-methyl-5-phenyl-, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methyl 2-methyl-5-phenylthiazole-4-carboxylate (133415-15-3) → 2-methyl-5-phenylthiazolecarbohydrazide (139156-69-7)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Heating;

DOI:10.1007/BF00959725

Reference yield:

methyl 3-phenyl-3-chloro-2-ketopropionate (32803-73-9) → 2-methyl-5-phenylthiazolecarbohydrazide (139156-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / ethanol / 3 h / Heating

2: 60 percent / 60percent hydrazine hydrate / ethanol / 5 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1007/BF00959725

Reference yield: 87.0%

phenyl isothiocyanate (103-72-0) + 2-methyl-5-phenylthiazolecarbohydrazide (139156-69-7) → 2-methyl-5-phenylthiazolecarboxylic acid 4-phenylthiosemicarbazide (139156-73-3)

Guidance literature:

In ethanol; for 4h; Heating;

DOI:10.1007/BF00959725

upstream raw materials:

methyl 2-methyl-5-phenylthiazole-4-carboxylate

methyl 3-phenyl-3-chloro-2-ketopropionate

Downstream raw materials:

2-(2'-methyl-5'-phenyl-4'-thiazolyl)-1,3,4-oxadiazole-5-thione

2-methyl-5-phenylthiazolecarboxylic acid thiosemicarbazide

2-methyl-5-phenylthiazolecarboxylic acid 4-phenylthiosemicarbazide

2-methyl-5-phenylthiazoline-4-carboxylic acid N-(3'-phenyl-4'-oxo-1',3'-thiazolidin-2'-ylidene)hydrazide