Benzoic acid 4-{(S)-2-[(S)-2-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-2-methoxycarbonyl-ethyl}-phenyl ester

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Chemical Name:Benzoic acid 4-{(S)-2-[(S)-2-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-2-methoxycarbonyl-ethyl}-phenyl ester
CAS No.:479207-67-5
Molecular Formula:C₄₉H₅₃N₃O₈S
Molecular Weight:844.041
Hs Code.:

Benzoic acid 4-{(S)-2-[(S)-2-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-2-methoxycarbonyl-ethyl}-phenyl ester

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Chemical Property of Benzoic acid 4-{(S)-2-[(S)-2-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-2-methoxycarbonyl-ethyl}-phenyl ester

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Technology Process of Benzoic acid 4-{(S)-2-[(S)-2-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-2-methoxycarbonyl-ethyl}-phenyl ester

There total 5 articles about Benzoic acid 4-{(S)-2-[(S)-2-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-2-methoxycarbonyl-ethyl}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 479207-67-5
Benzoic acid 4-{(S)-2-[(S)-2-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-2-methoxycarbonyl-ethyl}-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / EDC; HOBT; DIPEA / dimethylformamide / 16 h

2: 94 percent / H₂ / 10 percent Pd/C / methanol / 0.5 h

3: 80 percent / EDC; HOBT / tetrahydrofuran

4: DIPEA / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00227-5

Reference yield:

: 15149-72-1
N-(N-benzyloxycarbonyl-L-valyl)-L-tyrosine methyl ester

: 479207-67-5
Benzoic acid 4-{(S)-2-[(S)-2-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-2-methoxycarbonyl-ethyl}-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / H₂ / 10 percent Pd/C / methanol / 0.5 h

2: 80 percent / EDC; HOBT / tetrahydrofuran

3: DIPEA / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00227-5

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 479207-67-5
Benzoic acid 4-{(S)-2-[(S)-2-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-3-methyl-butyrylamino]-2-methoxycarbonyl-ethyl}-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / EDC; HOBT; DIPEA / dimethylformamide / 16 h

2: 94 percent / H₂ / 10 percent Pd/C / methanol / 0.5 h

3: 80 percent / EDC; HOBT / tetrahydrofuran

4: DIPEA / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00227-5