15149-72-1

Usage

Uses

Used in Pharmaceutical Research and Development:
N-CBZ-VAL-TYR METHYL ESTER is used as an intermediate in the synthesis of peptide-based drugs and pharmaceuticals for its ability to protect the amino acid side chains during the synthesis process. This protection allows for the controlled formation of peptide bonds and the creation of complex peptide structures.
Used in Peptide Synthesis:
N-CBZ-VAL-TYR METHYL ESTER is used as a protected dipeptide in the synthesis of larger peptides and proteins. The carbobenzyloxy group ensures that the side chains of the amino acids are not involved in unwanted side reactions, which is crucial for the successful synthesis of the desired peptide sequence.
Used in Enzyme Kinetics Studies:
N-CBZ-VAL-TYR METHYL ESTER is used as a substrate or inhibitor in enzyme kinetics studies to understand the mechanisms of enzymatic reactions involving peptides. Its protected structure allows for the investigation of enzyme specificity and activity under controlled conditions.
Used in Peptide Structure-Activity Relationship Studies:
N-CBZ-VAL-TYR METHYL ESTER is used in the study of the relationship between the structure of peptides and their biological activities. By synthesizing a series of related peptides with varying structures, researchers can gain insights into the factors that influence peptide function and activity.
Used in the Development of Drug Delivery Systems:
N-CBZ-VAL-TYR METHYL ESTER can be used in the development of drug delivery systems designed to improve the bioavailability and targeting of peptide-based therapeutics. Its protected structure can facilitate the design of delivery systems that release the active peptide in a controlled manner at the desired site of action.

InChI:InChI=1/C23H28N2O6/c1-15(2)20(25-23(29)31-14-17-7-5-4-6-8-17)21(27)24-19(22(28)30-3)13-16-9-11-18(26)12-10-16/h4-12,15,19-20,26H,13-14H2,1-3H3,(H,24,27)(H,25,29)

Upstream product

• 862-26-0 N^α-benzyloxycarbonylvalyltyrosine 
• 77-76-9 2,2-dimethoxy-propane 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 10512-93-3 Z-Val-ONp 
• 67-56-1 methanol 
• 5992-90-5 N-benzyloxycarbonylvalyltyrosine hydrazide 
• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 
• 1080-06-4 L-Tyr-OMe 

Downstream Products

• 14331-00-1 N-benzyloxycarbonyl-L-valyl=>L-tyrosyl=>L-valyl=>L-histidyl=>L-prolyl=>L-phenylalanine-methyl ester 
• 116607-02-4 N-benzyloxycarbonyl-L-valyl=>L-tyrosyl=>L-isoleucyl=>L-histidine-methyl ester 
• 41839-86-5 N-benzyloxycarbonyl-valyl->-tyrosyl->-valyl->-histidine methyl ester 
• 68759-86-4 N²-benzyloxycarbonyl-L-asparaginyl=>N^ω-nitro-L-arginyl=>L-valyl=>L-tyrosine methyl ester 
• 101636-44-6 N-benzyloxycarbonyl-L-valyl=>L-tyrosyl=>L-valine methyl ester 
• 3061-91-4 L-valyl-L-tyrosine 
• 58630-55-0 N-benzyloxycarbonyl-L-valine-((R)-4-hydroxy-α-isocyanato-phenethylamide) 
• 38188-90-8 N-(N-benzyloxycarbonyl-L-valyl)-L-tyrosyl azide 
• 79190-57-1 1-[N-(N-benzyloxycarbonyl-L-valyl)-L-tyrosyl]-L-proline-benzyl ester 
• 78819-67-7 valyltyrosylproline benzyl ester 
• 85471-58-5 H-L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH*3HOAc 
• 75958-14-4 Aspartyl-valyl-tyrosine 
• 127290-80-6 C₆₂H₇₃N₉O₁₇ 
• 90315-58-5 C₆₁H₇₆N₈O₁₂ 

Relevant academic research and scientific papers

Structures, sensory activity, and dose/response functions of 2,5-diketopiperazines in roasted cocoa nibs (Theobroma cacao)

The taste compounds inducing the blood-like, metallic bitter taste sensation reported recently for a dichloromethane extract prepared from roasted cocoa nibs were identified as a series of 25 diketopiperazines by means of HPLC degustation, LC-MS/MS, and i

Development of tripeptidyl farnesyltransferase inhibitors.

The first example of tripeptide inhibitors of farnesyltransferase with sub-micromolar inhibition activity was developed based on the fact that CVFM is not a substrate for farnesyltransferase.

2-Pyridon-1-yl Diphenyl Phosphate. A Useful New Reagent for the Synthesis of Amides and Peptides

2-Pyridon-1-yl diphenyl phosphate is found to be a useful coupling agent for the synthesis of amides and practically racemization-free peptides.

BENZOTRIAZOL-1-YL DIETHYL PHOSPHATE. A NEW CONVENIENT COUPLING REAGENT FOR THE SYNTHESIS OF AMIDES AND PEPTIDES.

Benzotriazol-1-yl diethyl phosphate is found to be a new convenient coupling reagent for the synthesis of amides and practically racemization-free peptides.

STUDIES OF BITTER PEPTIDES FROM CASEIN HYDROLYZATE - VI. SYNTHESES AND BITTER TASTE OF BPIc (VAL-TYR-PRO-PHE-PRO-PRO-GLY-ILE-ASN-HIS) AND ITS ANALOGS AND FRAGMENTS.

In order to investigate the relationship between chemical structure and bitter taste, the bitter peptide BPIc (Val-Tyr-Pro-Phe-Pro-Pro-Gly-Ile-Asn-His) isolated from casein hydrolyzate by Minamiura et al. and its analogs and fragments were synthesized. BPIc, whose threshold value of bitter taste was 0. 05 mm, was found to be one of the most bitter compounds, like quinine and phenylthiourea. However, left bracket Gly**5**,**6 right bracket - and left bracket Gly**9**,**1**0 right bracket -BPIc, and N-terminal octa- and heptapeptide fragments of BPIc possessed much weaker bitterness than BPIc. The results suggested that 5,6-proline and the basic nature of C-terminal are necessary for the strong bitterness exhibited by BPIc.

SYNTHESIS OF PEPTIDES CONTAINING HYDROXYAMINO ACIDS BY THE MIXED ANHYDRIDE METHOD WITHOUT PROTECTING THE HYDROXYL FUNCTIONS

Dimethylphosphinothioyl (Mpt) mixed anhydrides of N-protected amino acids were found to be isolatably stable and useful for the synthesis of hydroxyamino acid containing peptides without protecting the side-chain hydroxyl functions.They were applied for t

Mild Conversion of Carboxamides and Carboxylic Acid Hydrazides to Acids and Esters

A mild and selective conversion of unsubstituted carboxamides and carboxylic acid hydrazides to the corresponding acids and esters is brought about by the use of acidic resins.Application of the procedure to several carboxamides and carboxylic acid hydrazides is described.