(E)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone

Base Information

• Chemical Name: (E)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone
• CAS No.: 103869-88-1
• Molecular Formula: C₁₅H₁₈N₄O
• Molecular Weight: 270.334
• Mol file: 103869-88-1.mol

Synonyms:

Chemical Property of (E)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone

There total 1 articles about (E)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

N-4-methylphenylhydrazine (539-44-6) + 4-oxo-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazole (40345-59-3) → (E)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone (103869-88-1) + (Z)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone (103869-87-0)

Guidance literature:

In ethanol; for 1h; Yields of byproduct given; Heating;

DOI:10.1002/hlca.19850680630

Reference yield:

(E)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone (103869-88-1) → 4,5,6,7-tetrahydro-6,6-dimethyl-2-(p-tolyl)-2H-benzo<1,2,3>triazol-4-one oxime

Guidance literature:

With sodium ethanolate; In ethanol; for 1h; Yield given; Heating;

DOI:10.1002/hlca.19850680630

Reference yield:

(E)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone (103869-88-1) → 4,5,6,7-tetrahydro-6,6-dimethyl-2-phenyl-2H-benzo<1,2,3>triazol-4-one oxime

Guidance literature:

Multi-step reaction with 2 steps

1: 120 - 122 °C / isomerization

2: NaOEt / ethanol / Heating

With sodium ethanolate; In ethanol;

DOI:10.1002/hlca.19850680630

upstream raw materials:

N-4-methylphenylhydrazine

4-oxo-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazole

Downstream raw materials:

(Z)-4,5,6,7-tetrahydro-6,6-dimethylbenzo<1,2,5>oxadiazol-4-one (p-tolyl)hydrazone