Technology Process of 2-benzyloxy-4-bromo-3,6-dimethoxy-benzaldehyde
There total 1 articles about 2-benzyloxy-4-bromo-3,6-dimethoxy-benzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bromine; sodium acetate;
In
acetic acid;
at 20 ℃;
for 2h;
DOI:10.1002/ejoc.200600353
- Guidance literature:
-
With
tetra-N-butylammonium tribromide; trimethyl orthoformate;
In
dichloromethane;
at 20 ℃;
for 3h;
DOI:10.1002/ejoc.200600353
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 27.5 g / trimethyl ortoformate; tetra-n-butylammonium tribromide / CH2Cl2 / 3 h / 20 °C
2.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 24 h / -78 - 20 °C
3.1: 2,2-dimethylpropane-1,3-diol; trimethyl ortoformate; p-toluenesulfonic acid / CH2Cl2 / 19 h / Heating
3.2: 576 mg / pyridinium perbromide / tetrahydrofuran / 3 h / 20 °C / y
4.1: ceric ammonium bromide / H2O; acetonitrile / 1 h / 20 °C
5.1: tetra-n-butylammonium bromide; sodium dithionite / H2O; CH2Cl2 / 3 h / 20 °C
6.1: tetra-n-butylammonium bromide; sodium hydroxide / CH2Cl2; H2O / 15 h / 20 °C
With
sodium hydroxide; n-butyllithium; sodium dithionite; ceric ammonium bromide; tetrabutylammomium bromide; tetra-N-butylammonium tribromide; toluene-4-sulfonic acid; diisopropylamine; 2,2-Dimethyl-1,3-propanediol; trimethyl orthoformate;
In
tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;
2.1: Diels-Alder reaction;
DOI:10.1002/ejoc.200600353
