4-fluorobenzoyloxycinnamoyl chloride

Base Information

• Chemical Name: 4-fluorobenzoyloxycinnamoyl chloride
• CAS No.: 252192-82-8
• Molecular Formula: C₁₆H₁₀ClFO₃
• Molecular Weight: 304.705
• Mol file: 252192-82-8.mol

Synonyms:

Chemical Property of 4-fluorobenzoyloxycinnamoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluorobenzoyloxycinnamoyl chloride

There total 3 articles about 4-fluorobenzoyloxycinnamoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)‐3‐(4‐((4‐fluorobenzoyl)oxy)phenyl)acrylic acid (252192-78-2) → 4-fluorobenzoyloxycinnamoyl chloride (252192-82-8)

Guidance literature:

With thionyl chloride; In dichloromethane; at 40 ℃;

DOI:10.1039/b510731h

Reference yield:

p-Coumaric Acid (7400-08-0,50940-26-6) → 4-fluorobenzoyloxycinnamoyl chloride (252192-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / aq. NaOH / dimethylsulfoxide / 2 h / 20 °C

2: SOCl₂ / CH₂Cl₂ / 40 °C

With sodium hydroxide; thionyl chloride; In dichloromethane; dimethyl sulfoxide;

DOI:10.1039/b510731h

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → 4-fluorobenzoyloxycinnamoyl chloride (252192-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / aq. NaOH / dimethylsulfoxide / 2 h / 20 °C

2: SOCl₂ / CH₂Cl₂ / 40 °C

With sodium hydroxide; thionyl chloride; In dichloromethane; dimethyl sulfoxide;

DOI:10.1039/b510731h

upstream raw materials:

(E)‐3‐(4‐((4‐fluorobenzoyl)oxy)phenyl)acrylic acid

p-Coumaric Acid

4-fluorobenzoyl chloride