N-tert-butoxycarbonylglycyl-L-α-aminoadipic acid α-benzhydryl ester

Base Information

• Chemical Name: N-tert-butoxycarbonylglycyl-L-α-aminoadipic acid α-benzhydryl ester
• CAS No.: 77628-14-9
• Molecular Formula: C₂₆H₃₂N₂O₇
• Molecular Weight: 484.549
• Mol file: 77628-14-9.mol

Synonyms:

Chemical Property of N-tert-butoxycarbonylglycyl-L-α-aminoadipic acid α-benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonylglycyl-L-α-aminoadipic acid α-benzhydryl ester

There total 1 articles about N-tert-butoxycarbonylglycyl-L-α-aminoadipic acid α-benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate (3392-07-2) + α-L-aminoadipic acid α-benzhydryl ester (71264-13-6) → N-tert-butoxycarbonylglycyl-L-α-aminoadipic acid α-benzhydryl ester (77628-14-9)

Guidance literature:

With N-cyclohexyl-cyclohexanamine; Yield given. Multistep reaction; 1.) methanol, dimethoxyethane, 5 min; 2.) 24 h;

DOI:10.1139/v81-062

Reference yield: 78.0%

6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt (77628-11-6) + N-tert-butoxycarbonylglycyl-L-α-aminoadipic acid α-benzhydryl ester (77628-14-9) → (3S,6R)-6-[(S)-5-Benzhydryloxycarbonyl-5-(2-tert-butoxycarbonylamino-acetylamino)-pentanoylamino]-2,2-dimethyl-5-oxo-[1,4]thiazepane-3-carboxylic acid benzhydryl ester (77628-16-1)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline;

DOI:10.1139/v81-062

Reference yield:

N-tert-butoxycarbonylglycyl-L-α-aminoadipic acid α-benzhydryl ester (77628-14-9) → (1R,3S,6R)-6-[(S)-5-Benzhydryloxycarbonyl-5-(2-tert-butoxycarbonylamino-acetylamino)-pentanoylamino]-2,2-dimethyl-1,5-dioxo-1λ4-[1,4]thiazepane-3-carboxylic acid benzhydryl ester (77628-18-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

2: 91 percent / 85percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.33 h / 2 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1139/v81-062

upstream raw materials:

tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate

α-L-aminoadipic acid α-benzhydryl ester

Downstream raw materials:

(3S,6R)-6-[(S)-5-Benzhydryloxycarbonyl-5-(2-tert-butoxycarbonylamino-acetylamino)-pentanoylamino]-2,2-dimethyl-5-oxo-[1,4]thiazepane-3-carboxylic acid benzhydryl ester

(1R,3S,6R)-6-[(S)-5-Benzhydryloxycarbonyl-5-(2-tert-butoxycarbonylamino-acetylamino)-pentanoylamino]-2,2-dimethyl-1,5-dioxo-1λ⁴-[1,4]thiazepane-3-carboxylic acid benzhydryl ester