1H-Indole-1-butanoic acid, 3-(4-aminobenzoyl)-

Base Information

Chemical Name:1H-Indole-1-butanoic acid, 3-(4-aminobenzoyl)-
CAS No.:139176-76-4
Molecular Formula:C19H18N2O3
Molecular Weight:322.364
Hs Code.:

Synonyms:

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Chemical Property of 1H-Indole-1-butanoic acid, 3-(4-aminobenzoyl)-

Chemical Property:

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Technology Process of 1H-Indole-1-butanoic acid, 3-(4-aminobenzoyl)-

There total 5 articles about 1H-Indole-1-butanoic acid, 3-(4-aminobenzoyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.2%

: 139155-52-5
4-[3-(4-nitrobenzoyl)-1H-indol-1-yl]butyric acid

: 139176-76-4
4-[3-(4-aminobenzoyl)-1H-indol-1-yl]butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; ethanol; for 4h; under 3040 Torr;
DOI:10.1248/cpb.49.799

Reference yield:

: 120-72-9
indole

: 139176-76-4
4-[3-(4-aminobenzoyl)-1H-indol-1-yl]butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: AlCl₃ / CH₂Cl₂ / 0.17 h / 20 °C

1.2: 34.3 percent / CH₂Cl₂ / 1 h

2.1: 83.9 percent / K₂CO₃ / dimethylformamide / 4 h / 50 °C

3.1: 93.2 percent / 4N aq. NaOH / ethanol / 0.67 h / Heating

4.1: 71.2 percent / H₂ / 10 percent Pd/C / dioxane; ethanol / 4 h / 3040 Torr

With sodium hydroxide; aluminium trichloride; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 139176-76-4
4-[3-(4-aminobenzoyl)-1H-indol-1-yl]butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: AlCl₃ / CH₂Cl₂ / 0.17 h / 20 °C

1.2: 34.3 percent / CH₂Cl₂ / 1 h

2.1: 83.9 percent / K₂CO₃ / dimethylformamide / 4 h / 50 °C

3.1: 93.2 percent / 4N aq. NaOH / ethanol / 0.67 h / Heating

4.1: 71.2 percent / H₂ / 10 percent Pd/C / dioxane; ethanol / 4 h / 3040 Torr

With sodium hydroxide; aluminium trichloride; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799