trans-<2'-methyl-2'-(prop-2''-enyl)cyclohexyl>propanedinitrile

Base Information

• Chemical Name: trans-<2'-methyl-2'-(prop-2''-enyl)cyclohexyl>propanedinitrile
• CAS No.: 131581-05-0
• Molecular Formula: C₁₃H₁₈N₂
• Molecular Weight: 202.299
• Mol file: 131581-05-0.mol

Synonyms:

Chemical Property of trans-<2'-methyl-2'-(prop-2''-enyl)cyclohexyl>propanedinitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-<2'-methyl-2'-(prop-2''-enyl)cyclohexyl>propanedinitrile

There total 2 articles about trans-<2'-methyl-2'-(prop-2''-enyl)cyclohexyl>propanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2-allylcyclohexanone (16178-87-3) → cis-<2'-methyl-2'-(prop-2''-enyl)cyclohexyl>propanedinitrile (131581-05-0,131581-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / β-alanine, acetic acid, piperidine / benzene / 72 h / Heating

2: 272 mg / NaBH₄ / ethanol / 0.25 h

With piperidine; sodium tetrahydroborate; acetic acid; 3-amino propanoic acid; In ethanol; benzene;

DOI:10.1071/CH9901309

Reference yield:

2-methyl-2-allylcyclohexanone (16178-87-3) → trans-<2'-methyl-2'-(prop-2''-enyl)cyclohexyl>propanedinitrile (131581-05-0,131581-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / β-alanine, acetic acid, piperidine / benzene / 72 h / Heating

2: 112 mg / NaBH₄ / ethanol / 0.25 h

With piperidine; sodium tetrahydroborate; acetic acid; 3-amino propanoic acid; In ethanol; benzene;

DOI:10.1071/CH9901309

Reference yield:

2-(2-Allyl-2-methyl-cyclohexyl)-malononitrile (131581-05-0,131581-06-1) → (1'R*,2'R*.2''S*)-<2'-(3''-bromo-2''-hydroxypropyl)-2'-methylcyclohexyl>propanedinitrile (92403-92-4,131616-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: m-chloroperbenzoic acid, 4,4'-thiobis(6-t-butyl-3-methylphenol / 1,2-dichloro-ethane / 2 h / Heating

2: 60 percent / dilithium tetrabromonickelate(II) / tetrahydrofuran / 3 h / 24 °C

With dilithium tetrabromonickelate(II); 2,2'-Dimethyl-5,5'-di-tert-butyl-4,4'-dihydroxy-diphenyl-sulfid, Lanotox; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1071/CH9901309

upstream raw materials:

2-methyl-2-allylcyclohexanone

Downstream raw materials:

(1'R*,2'R*,2''R*)-<2'-(2'',3''-epoxypropyl)-2'-methylcyclohexyl>propanedinitrile

(1'R*,2'R*,2''S*)-<2'-(2'',3''-epoxypropyl)-2'-methylcyclohexyl>propanedinitrile

(1'R*,2'S*,2''S*)-<2'-(2'',3''-epoxypropyl)-2'-methylcyclohexyl>propanedinitrile

(1'R*,2'S*,2''R*)-<2'-(2'',3''-epoxypropyl)-2'-methylcyclohexyl>propanedinitrile