N-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide

Base Information

Chemical Name:N-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide
CAS No.:908143-21-5
Molecular Formula:C₄₇H₆₂BrN₇O₇Si
Molecular Weight:945.041
Hs Code.:

<i>N</i>-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-6-yl]-formamide

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Chemical Property of N-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide

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Technology Process of N-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide

There total 5 articles about N-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 908143-20-4
N-[1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: N-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide

: 908143-21-5
N-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide

Guidance literature:: With pyridine; silver nitrate; In tetrahydrofuran;
DOI:10.1081/NCN-200059218

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 908143-21-5
N-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 70 percent / BF₃*Et₂O / nitromethane / Heating

2.1: 76 percent / NaOMe; MeOH

3.1: methanol / 20 °C

3.2: 33 percent / pyridine

4.1: 38 percent / AgNO₃; pyridine / tetrahydrofuran

With pyridine; methanol; sodium methylate; silver nitrate; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; nitromethane;
DOI:10.1081/NCN-200059218

Reference yield:

: 144750-82-3
2,4-Diamino-5-bromo-7H-pyrazolo<3,4-d>pyrimidine

: 908143-21-5
N-[1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-3-bromo-4-(dibutylamino-methyleneamino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-formamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 70 percent / BF₃*Et₂O / nitromethane / Heating

2.1: 76 percent / NaOMe; MeOH

3.1: methanol / 20 °C

3.2: 33 percent / pyridine

4.1: 38 percent / AgNO₃; pyridine / tetrahydrofuran

With pyridine; methanol; sodium methylate; silver nitrate; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; nitromethane;
DOI:10.1081/NCN-200059218