C₃₀H₃₁FN₈O₅

Base Information

• Chemical Name: C₃₀H₃₁FN₈O₅
• CAS No.: 619331-10-1
• Molecular Formula: C₃₀H₃₁FN₈O₅
• Molecular Weight: 602.625
• Mol file: 619331-10-1.mol

Synonyms:

Chemical Property of C₃₀H₃₁FN₈O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₁FN₈O₅

There total 8 articles about C₃₀H₃₁FN₈O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + C26H23FN6O5 → C30H31FN8O5 (619331-10-1)

Guidance literature:

With ammonia; In methanol; at 70 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1021/jm3016377

Reference yield:

6-methoxy-pyridin-3-ylamine (6628-77-9) → C30H31FN8O5 (619331-10-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: tetrafluoroboric acid; sodium nitrite / ethanol; water / 3 h / 0 °C / Inert atmosphere

1.2: 4 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / toluene / 2 h / Inert atmosphere; Sealed tube; Heating

3.1: sulfuric acid; nitric acid / 1 h / 20 - 80 °C / Inert atmosphere

4.1: tetrahydrofuran / 2.25 h / Inert atmosphere; Cooling

5.1: aluminum (III) chloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride / 8 h / 20 °C / Inert atmosphere

5.2: Inert atmosphere; Cooling with ice

6.1: N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / Inert atmosphere; Sealed tube; Heating

8.1: ammonia / methanol / 48 h / 70 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; aluminum (III) chloride; tetrafluoroboric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ammonia; nitric acid; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; 4.1: |Bartoli Indole Synthesis / 7.1: |Stille Cross Coupling;

DOI:10.1021/jm3016377

Reference yield:

5-fluoro-2-methoxypyridine (51173-04-7) → C30H31FN8O5 (619331-10-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: hydrogenchloride / toluene / 2 h / Inert atmosphere; Sealed tube; Heating

2.1: sulfuric acid; nitric acid / 1 h / 20 - 80 °C / Inert atmosphere

3.1: tetrahydrofuran / 2.25 h / Inert atmosphere; Cooling

4.1: aluminum (III) chloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride / 8 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere; Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / Inert atmosphere; Sealed tube; Heating

7.1: ammonia / methanol / 48 h / 70 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ammonia; nitric acid; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; 3.1: |Bartoli Indole Synthesis / 6.1: |Stille Cross Coupling;

DOI:10.1021/jm3016377

upstream raw materials:

4-(2-AMINOETHYL)MORPHOLINE

6-methoxy-pyridin-3-ylamine

5-fluoro-2-methoxypyridine

5-fluoropyridin-2-ol