5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Base Information

Chemical Name:5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
CAS No.:220891-52-1
Molecular Formula:C₃₈H₄₃N₃O₈
Molecular Weight:669.775
Hs Code.:

5-({[1-benzyloxycarbonyl-2-(1<i>H</i>-indol-3-yl)-ethyl]-<i>tert</i>-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Chemical Property of 5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Technology Process of 5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

There total 7 articles about 5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102508-03-2
cis-2,5-dimethyl N-benzylpyrrolidine-2,5-dicarboxylate

: 220891-52-1
5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 10 percent Pd-C / methanol / 3102.89 Torr

2: NaHCO₃ / ethyl acetate; H₂O

3: NaBH₄ / methanol; tetrahydrofuran / 25 °C

4: (COCl)2, DMSO, Et₃N / -78 - 25 °C

5: NaBH₃CN / methanol; acetic acid / 25 °C

6: acetonitrile / 25 °C

With sodium tetrahydroborate; oxalyl dichloride; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetic acid; ethyl acetate; acetonitrile;

Reference yield:

: 116836-63-6,610284-42-9
cis-2,5-dimethyl pyrrolidine-2,5-dicarboxylate

: 220891-52-1
5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaHCO₃ / ethyl acetate; H₂O

2: NaBH₄ / methanol; tetrahydrofuran / 25 °C

3: (COCl)2, DMSO, Et₃N / -78 - 25 °C

4: NaBH₃CN / methanol; acetic acid / 25 °C

5: acetonitrile / 25 °C

With sodium tetrahydroborate; oxalyl dichloride; sodium cyanoborohydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; water; acetic acid; ethyl acetate; acetonitrile;

Reference yield:

: 22328-84-3
cis-N-carbobenzoxy-2,5-dicarbomethoxypyrrolidine

: 220891-52-1
5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / methanol; tetrahydrofuran / 25 °C

2: (COCl)2, DMSO, Et₃N / -78 - 25 °C

3: NaBH₃CN / methanol; acetic acid / 25 °C

4: acetonitrile / 25 °C

With sodium tetrahydroborate; oxalyl dichloride; sodium cyanoborohydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; acetic acid; acetonitrile;