22328-84-3

Upstream product

• 868-72-4 dimethyl (2R,5S)-2,5-dibromohexanedioate 
• 102107-98-2 5(S)-(hydroxymethyl)-2,2-dicarbethoxypyrrolidine 
• 102208-90-2 5(S)-(hydroxymethyl)-2(R)-carboxypyrrolidine 
• 501-53-1 benzyl chloroformate 
• 102508-03-2 cis-2,5-dimethyl N-benzylpyrrolidine-2,5-dicarboxylate 
• 116836-63-6 cis-2,5-dimethyl pyrrolidine-2,5-dicarboxylate 
• 186581-53-3 diazomethane 
• 102108-02-1 (2S,5R)-Pyrrolidine-1,2,5-tricarboxylic acid 1-benzyl ester 2-methyl ester 
• 102108-00-9 N-carbobenzoxy-5(S)-(hydroxymethyl)-2(R)-carbomethoxypyrrolidine 
• 102108-01-0 (2S,5R)-1-(benzyloxycarbonyl)-5-(hydroxymethyl)pyrrolidine-2-carboxylic acid 

Downstream Products

• 943620-86-8 C₁₈H₂₂ClNO₆ 
• 220891-51-0 (2S,5R)-5-{[(R)-1-Benzyloxycarbonyl-2-(1H-indol-3-yl)-ethylamino]-methyl}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 220891-48-5 (2R,5S)-5-{[(R)-1-Benzyloxycarbonyl-2-(1H-indol-3-yl)-ethylamino]-methyl}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 220891-52-1 5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 220891-49-6 5-({[1-benzyloxycarbonyl-2-(1H-indol-3-yl)-ethyl]-tert-butoxycarbonyl-amino}-methyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 1198569-68-4 1-benzyl 2,5-dimethyl 2,5-bis(3-chloropropyl)pyrrolidine-1,2,5-tricarboxylate 
• 191850-97-2 cis-1-benzyl 2,5-bis(hydroxymethyl)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

Synthesis of a conformationally rigid analogue of 2-aminoadipic acid containing an 8-azabicyclo[3.2.1]octane skeleton

A new, conformationally rigid analogue of 2-aminoadipic acid, 8-[(benzyloxy)carbonyl]-3-methylene-8-azabicyclo[3.2.1]octane-1,5-dicarboxylic acid, is synthesized from dimethyl rac-2,5-dibromohexanedioate. The key steps involve alkylation-cyclization of 1-

Synthesis of 7-azabicyclo[2.2.1]heptane-1,4-dicarboxylic acid, a rigid non-chiral analogue of 2-aminoadipic acid

A non-chiral, rigid 7-azabicyclo[2.2.1]heptane-1,4-dicarboxylic acid, an analogue of 2-aminoadipic acid, has been synthesized in six steps from dimethyl-meso-2,5-dibromohexanedioate in 28% total yield. A key step in the synthesis is double alkylation of a

HIV protease inhibitors

Combinatorial libraries of HIV and FIV protease inhibitors are characterized by alpha-keto amide or hydroxyethylamine core structures flanked by on one side by substituted pyrrolidines, piperidines, or azasugars and on the other side by phenylalanine, tyrosine, or substituted tyrosines. The libraries are synthesized via a one step coupling reaction. Highly efficacious drug candidates are identified by screening the libraries for binding and inhibitory activity against both HIV and FIV protease. Drug candidates displaying clinically useful activity against both HIV and FIV protease are identified as being potentially resistive against a loss of inhibitory activity due to development of resistant strains of HIV.

Design and synthesis of 1,4-diazabicyclo[4.3.0]Nonane peptidomimetic endothelin antagonists

The design and synthesis of a series of 2-(3-indolylmethyl)-4-(tert- butoxycarbonyl)-1,4-diaza-2-oxobicyclo[4.3.0]nonane-9-carboxylic acid peptidomimetics based on the peptide endothelin antagonists BQ-123 and FR139317 were described. The stereochemistry