N²-acetyl-L-leucyl-L-leucyl-N⁷,N⁷'-bis<(benzyloxy)carbonyl>-L-argininal

Base Information

• Chemical Name: N²-acetyl-L-leucyl-L-leucyl-N⁷,N⁷'-bis<(benzyloxy)carbonyl>-L-argininal
• CAS No.: 1027478-75-6
• Molecular Formula: C₃₆H₅₀N₆O₈
• Molecular Weight: 694.828
• Mol file: 1027478-75-6.mol

Synonyms:

Chemical Property of N²-acetyl-L-leucyl-L-leucyl-N⁷,N⁷'-bis<(benzyloxy)carbonyl>-L-argininal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-acetyl-L-leucyl-L-leucyl-N⁷,N⁷'-bis<(benzyloxy)carbonyl>-L-argininal

There total 6 articles about N²-acetyl-L-leucyl-L-leucyl-N⁷,N⁷'-bis<(benzyloxy)carbonyl>-L-argininal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2-acetyl-L-leucyl-L-leucyl-N7,N7'-bis<(benzyloxy)carbonyl>-L-arginine phenyl ester (1053261-36-1) → N2-acetyl-L-leucyl-L-leucyl-N7,N7'-bis<(benzyloxy)carbonyl>-L-argininal (1027478-75-6)

Guidance literature:

With tri-tert-butoxyaluminum hydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1002/hlca.19940770117

Reference yield:

N-Ac-Leu (1188-21-2) → N2-acetyl-L-leucyl-L-leucyl-N7,N7'-bis<(benzyloxy)carbonyl>-L-argininal (1027478-75-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) N-hydroxysuccinimide, dicyclohexylcarbodiimide; 2.) Na₂CO₃ / 1.) acetonitrile, r.t., 6 h; 2.) acetonitrile, H₂O

2: 1.) N-hydroxysuccinimide, dicyclohexylcarbodiimide; 2.) Na₂CO₃ / 1.) acetonitrile, r.t.; 2.) acetonitrile, H₂O, r.t., 6 h

3: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran; acetonitrile / Ambient temperature

4: tri(tert-butoxy)aluminium hydride / tetrahydrofuran / 1 h / 0 °C

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; sodium carbonate; tri-tert-butoxyaluminum hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile;

DOI:10.1002/hlca.19940770117

Reference yield:

-L-leucine (24125-26-6) → N2-acetyl-L-leucyl-L-leucyl-N7,N7'-bis<(benzyloxy)carbonyl>-L-argininal (1027478-75-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) N-hydroxysuccinimide, dicyclohexylcarbodiimide; 2.) Na₂CO₃ / 1.) acetonitrile, r.t.; 2.) acetonitrile, H₂O, r.t., 6 h

2: dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran; acetonitrile / Ambient temperature

3: tri(tert-butoxy)aluminium hydride / tetrahydrofuran / 1 h / 0 °C

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; sodium carbonate; tri-tert-butoxyaluminum hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile;

DOI:10.1002/hlca.19940770117

upstream raw materials:

N²-acetyl-L-leucyl-L-leucyl-N⁷,N⁷'-bis<(benzyloxy)carbonyl>-L-arginine phenyl ester

-L-leucine

L-leucine

N-Ac-Leu