Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester
• CAS No.: 169687-93-8
• Molecular Formula: C₃₃H₅₁F₃N₆O₇SSi₂
• Molecular Weight: 789.036
• Mol file: 169687-93-8.mol

Synonyms:

Chemical Property of Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

There total 8 articles about Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

trifluoromethane sulfonyl chloride (421-83-0) + (2R,3R,3aS,9aR)-2-[6-Amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol (205445-24-5) → Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester (169687-93-8)

Guidance literature:

With dmap; triethylamine; In pyridine; for 3.5h; Ambient temperature;

Reference yield:

2-(4-butyl-anilino)-adenosine (169687-92-7) → Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester (169687-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92.1 percent / imidazole / dimethylformamide / 2.5 h / Ambient temperature

2: 79 percent / DMAP, Et₃N / pyridine / 3.5 h / Ambient temperature

With 1H-imidazole; dmap; triethylamine; In pyridine; N,N-dimethyl-formamide;

Reference yield:

4-Butylaniline (104-13-2) → Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester (169687-93-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 75.9 percent / methanol / 4 h / 95 °C

2: 1.) Et₄NCl, N,N-dimethylaniline, POCl₃, 2.) NH₃/MeOH / 1.) MeCN, 80 deg C, 1 h, 2.) 120 deg C, 5 h

3: 92.1 percent / imidazole / dimethylformamide / 2.5 h / Ambient temperature

4: 79 percent / DMAP, Et₃N / pyridine / 3.5 h / Ambient temperature

With 1H-imidazole; methanol; dmap; tetraethylammonium chloride; ammonia; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In pyridine; methanol; N,N-dimethyl-formamide;

upstream raw materials:

trifluoromethane sulfonyl chloride

(2R,3R,3aS,9aR)-2-[6-Amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol

2-(4-butyl-anilino)-adenosine

4-Butylaniline

Downstream raw materials:

9-((2R,3S,3aR,9aR)-3-Bromo-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-N²-(4-butyl-phenyl)-9H-purine-2,6-diamine

Acetic acid (2R,3S,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

9-((2R,3S,3aS,9aR)-3-Azido-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-N²-(4-butyl-phenyl)-9H-purine-2,6-diamine

2-(p-n-butylanilino)-2'-deoxyadenosine