Acetic acid (2R,3S,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

Base Information

• Chemical Name: Acetic acid (2R,3S,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester
• CAS No.: 169687-95-0
• Molecular Formula: C₃₄H₅₄N₆O₆Si₂
• Molecular Weight: 699.01
• Mol file: 169687-95-0.mol

Synonyms:

Chemical Property of Acetic acid (2R,3S,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (2R,3S,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

There total 9 articles about Acetic acid (2R,3S,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

sodium acetate (127-09-3) + Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester (169687-93-8) → Acetic acid (2R,3S,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester (169687-95-0)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; for 4h; Ambient temperature;

Reference yield:

2-(4-butyl-anilino)-adenosine (169687-92-7) → Acetic acid (2R,3S,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester (169687-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 92.1 percent / imidazole / dimethylformamide / 2.5 h / Ambient temperature

2: 79 percent / DMAP, Et₃N / pyridine / 3.5 h / Ambient temperature

3: 44 percent / hexamethylphosphoric acid triamide / 4 h / Ambient temperature

With 1H-imidazole; dmap; triethylamine; In pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;

Reference yield:

4-Butylaniline (104-13-2) → Acetic acid (2R,3S,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester (169687-95-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 75.9 percent / methanol / 4 h / 95 °C

2: 1.) Et₄NCl, N,N-dimethylaniline, POCl₃, 2.) NH₃/MeOH / 1.) MeCN, 80 deg C, 1 h, 2.) 120 deg C, 5 h

3: 92.1 percent / imidazole / dimethylformamide / 2.5 h / Ambient temperature

4: 79 percent / DMAP, Et₃N / pyridine / 3.5 h / Ambient temperature

5: 44 percent / hexamethylphosphoric acid triamide / 4 h / Ambient temperature

With 1H-imidazole; methanol; dmap; tetraethylammonium chloride; ammonia; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;

upstream raw materials:

sodium acetate

Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester

2-(4-butyl-anilino)-adenosine

4-Butylaniline

Downstream raw materials:

(2R,3S,4S,5R)-2-[6-Amino-2-(4-butyl-phenylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Phosphoric acid mono-{(2R,3S,4S,5R)-5-[6-amino-2-(4-butyl-phenylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl} ester