(S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-methyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-methyl-amino}-benzoylamino)-pentanedioic acid diethyl ester
CAS No.:1053636-20-6
Molecular Formula:C₂₆H₃₆N₆O₅
Molecular Weight:512.609
Hs Code.:

(S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-methyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Synonyms:

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Chemical Property of (S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-methyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Chemical Property:

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Technology Process of (S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-methyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

There total 11 articles about (S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-methyl-amino}-benzoylamino)-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94-09-7
p-aminoethylbenzoate

: 1053636-20-6
(S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-methyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 87 percent / N,N-diisopropylethylamine / dimethylformamide / 24 h / 70 °C

2: 63 percent / NaHCO₃ / 1 h / 90 °C

3: 55 percent / 1N NaOH / ethanol

4: 95 percent / NaBH₄

5: Et₃N

6: 93 percent / NaI

7: Bu₃SnH, AIBN / benzene / Heating

8: iso-Pr₂EtN / methanol

9: 59 percent

10: 96 percent / 1N HCl / acetic acid

11: 1.) CDI, 2.) Et₃N

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium iodide; In methanol; ethanol; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.43.829

Reference yield:

: 149326-00-1
ethyl 4-benzoate

: 1053636-20-6
(S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-methyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N

2: 93 percent / NaI

3: Bu₃SnH, AIBN / benzene / Heating

4: iso-Pr₂EtN / methanol

5: 59 percent

6: 96 percent / 1N HCl / acetic acid

7: 1.) CDI, 2.) Et₃N

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium iodide; In methanol; acetic acid; benzene;
DOI:10.1248/cpb.43.829

Reference yield:

: 170799-72-1
ethyl 4-benzoate

: 1053636-20-6
(S)-2-(4-{[2-(2,4-Diamino-6,7-dihydro-5H-cyclopentapyrimidin-5-yl)-ethyl]-methyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Bu₃SnH, AIBN / benzene / Heating

2: iso-Pr₂EtN / methanol

3: 59 percent

4: 96 percent / 1N HCl / acetic acid

5: 1.) CDI, 2.) Et₃N

With hydrogenchloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In methanol; acetic acid; benzene;
DOI:10.1248/cpb.43.829