{(S)-2-Benzylsulfanyl-1-[(R)-2-benzylsulfanyl-1-((R)-2-benzylsulfanyl-1-carbamoyl-1-methyl-ethylcarbamoyl)-1-methyl-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester

Base Information

Chemical Name:{(S)-2-Benzylsulfanyl-1-[(R)-2-benzylsulfanyl-1-((R)-2-benzylsulfanyl-1-carbamoyl-1-methyl-ethylcarbamoyl)-1-methyl-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester
CAS No.:191734-57-3
Molecular Formula:C₄₁H₄₈N₄O₅S₃
Molecular Weight:773.054
Hs Code.:

{(S)-2-Benzylsulfanyl-1-[(R)-2-benzylsulfanyl-1-((R)-2-benzylsulfanyl-1-carbamoyl-1-methyl-ethylcarbamoyl)-1-methyl-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {(S)-2-Benzylsulfanyl-1-[(R)-2-benzylsulfanyl-1-((R)-2-benzylsulfanyl-1-carbamoyl-1-methyl-ethylcarbamoyl)-1-methyl-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of {(S)-2-Benzylsulfanyl-1-[(R)-2-benzylsulfanyl-1-((R)-2-benzylsulfanyl-1-carbamoyl-1-methyl-ethylcarbamoyl)-1-methyl-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester

There total 10 articles about {(S)-2-Benzylsulfanyl-1-[(R)-2-benzylsulfanyl-1-((R)-2-benzylsulfanyl-1-carbamoyl-1-methyl-ethylcarbamoyl)-1-methyl-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155104-38-4
N^α-benzyloxycarbonyl-S-benzyl-(S)-methylcysteine

: (R)-2-((R)-2-Amino-3-benzylsulfanyl-2-methyl-propionylamino)-3-benzylsulfanyl-2-methyl-propionamide

: 191734-57-3
{(S)-2-Benzylsulfanyl-1-[(R)-2-benzylsulfanyl-1-((R)-2-benzylsulfanyl-1-carbamoyl-1-methyl-ethylcarbamoyl)-1-methyl-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 24h; Yield given;
DOI:10.1016/S0040-4020(97)00523-1

Reference yield:

: 15960-81-3
benzyl bromomethyl thioether

: 191734-57-3
{(S)-2-Benzylsulfanyl-1-[(R)-2-benzylsulfanyl-1-((R)-2-benzylsulfanyl-1-carbamoyl-1-methyl-ethylcarbamoyl)-1-methyl-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / LiNEt₂ / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 deg C, 4 h, warm to 0 deg C

2: LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

3: DIEA, HOAt, CIP / CH₂Cl₂ / 24 h / 25 °C

4: HBr, AcOH / CH₂Cl₂ / 1 h / 25 °C

5: DIEA, HOAt, CIP / CH₂Cl₂ / 24 h / 25 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; lithium diethylamide; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1016/S0040-4020(97)00523-1

Reference yield:

: 143564-90-3
(2R,4R)-4-Benzylsulfanylmethyl-4-methyl-5-oxo-2-phenyl-oxazolidine-3-carboxylic acid benzyl ester

: 191734-57-3
{(S)-2-Benzylsulfanyl-1-[(R)-2-benzylsulfanyl-1-((R)-2-benzylsulfanyl-1-carbamoyl-1-methyl-ethylcarbamoyl)-1-methyl-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

2: DIEA, HOAt, CIP / CH₂Cl₂ / 24 h / 25 °C

3: HBr, AcOH / CH₂Cl₂ / 1 h / 25 °C

4: DIEA, HOAt, CIP / CH₂Cl₂ / 24 h / 25 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(97)00523-1