N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide 1,3-dihydroxy-2-(hydroxymethyl)propan-2-ammonium

Base Information

• Chemical Name: N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide 1,3-dihydroxy-2-(hydroxymethyl)propan-2-ammonium
• CAS No.: 1187992-94-4
• Molecular Formula: C₄H₁₁NO₃*C₂₄H₂₁N₅O₄
• Molecular Weight: 564.598
• Mol file: 1187992-94-4.mol

Synonyms:

Chemical Property of N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide 1,3-dihydroxy-2-(hydroxymethyl)propan-2-ammonium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide 1,3-dihydroxy-2-(hydroxymethyl)propan-2-ammonium

There total 4 articles about N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide 1,3-dihydroxy-2-(hydroxymethyl)propan-2-ammonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (1187990-87-9) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide 1,3-dihydroxy-2-(hydroxymethyl)propan-2-ammonium (1187992-94-4)

Guidance literature:

In N,N-dimethyl-formamide; for 0.0333333h; Heating;

Reference yield:

4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxylic acid (1187992-93-3) → N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide 1,3-dihydroxy-2-(hydroxymethyl)propan-2-ammonium (1187992-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 120 °C

1.2: 1 h / 115 °C

2.1: N,N-dimethyl-formamide / 0.03 h / Heating

With triethylamine; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;

Reference yield:

pyridazine-3-carbonitrile (53896-49-4) → N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide 1,3-dihydroxy-2-(hydroxymethyl)propan-2-ammonium (1187992-94-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 20 °C

1.2: 2.5 h / Reflux

2.1: sodium methylate / methanol; ethanol / 0.33 h / 120 °C / microwave

2.2: 0.17 h / 120 °C / microwave

2.3: 0.25 h / pH 2

3.1: triethylamine; 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 120 °C

3.2: 1 h / 115 °C

4.1: N,N-dimethyl-formamide / 0.03 h / Heating

With sodium methylate; triethylamine; 1,1'-carbonyldiimidazole; In methanol; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

N-[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide

2-amino-2-hydroxymethyl-1,3-propanediol

4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxylic acid

pyridazine-3-carbonitrile