Technology Process of 2-Amino-3-((E)-1-benzyloxymethyl-penta-2,4-dienyl)-5-methoxy-6-methyl-[1,4]benzoquinone
There total 17 articles about 2-Amino-3-((E)-1-benzyloxymethyl-penta-2,4-dienyl)-5-methoxy-6-methyl-[1,4]benzoquinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper acetylacetonate;
In
benzene;
for 3h;
Heating;
DOI:10.1246/cl.1983.1383
- Guidance literature:
-
Multi-step reaction with 14 steps
1: 100 percent / LiAlH4
2: 95.6 percent / PBr3
3: 88 percent / K2CO3 / acetone / Heating
4: 84 percent / N,N-dimethylaniline / 200 °C
5: K2CO3 / acetone
6: 1.) KOH; 2.) imidazole / 1.) MeOH, 0 deg C; 2.) DMF
7: 1.) BH3*SMe2; 2.) 30 percent H2O2, NaOH / 1.) Et2O, 0 deg C; 2.) EtOH
8: pyridinium chlorochromate / CH2Cl2
9: tetrahydrofuran / 0 °C
10: Et3N / 1 h / 0 °C
11: 78 percent / Al2O3 / diethyl ether / 4 h
12: CAN / acetonitrile
13: NaN3 / ethanol
14: 5 percent / Cu(acac)2 / benzene / 3 h / Heating
With
1H-imidazole; aluminum oxide; copper acetylacetonate; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; ammonium cerium(IV) nitrate; dimethylsulfide borane complex; dihydrogen peroxide; phosphorus tribromide; potassium carbonate; N,N-dimethyl-aniline; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone; acetonitrile; benzene;
DOI:10.1246/cl.1983.1383
- Guidance literature:
-
Multi-step reaction with 13 steps
1: Cl2CHOCH3
2: 88 percent / K2CO3 / acetone / Heating
3: 84 percent / N,N-dimethylaniline / 200 °C
4: K2CO3 / acetone
5: 1.) KOH; 2.) imidazole / 1.) MeOH, 0 deg C; 2.) DMF
6: 1.) BH3*SMe2; 2.) 30 percent H2O2, NaOH / 1.) Et2O, 0 deg C; 2.) EtOH
7: pyridinium chlorochromate / CH2Cl2
8: tetrahydrofuran / 0 °C
9: Et3N / 1 h / 0 °C
10: 78 percent / Al2O3 / diethyl ether / 4 h
11: CAN / acetonitrile
12: NaN3 / ethanol
13: 5 percent / Cu(acac)2 / benzene / 3 h / Heating
With
1H-imidazole; aluminum oxide; copper acetylacetonate; potassium hydroxide; sodium hydroxide; sodium azide; ammonium cerium(IV) nitrate; Dichloromethyl methyl ether; dimethylsulfide borane complex; dihydrogen peroxide; potassium carbonate; N,N-dimethyl-aniline; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetone; acetonitrile; benzene;
DOI:10.1246/cl.1983.1383
