N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide

Base Information

Chemical Name:N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide
CAS No.:1192021-71-8
Molecular Formula:C₁₅H₁₂ClF₃N₂O₂
Molecular Weight:344.721
Hs Code.:

Synonyms:

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Chemical Property of N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide

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Technology Process of N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide

There total 6 articles about N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14906-62-8
3-ethylpyridine N-oxide

: 1192021-71-8
N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethyl iodide / 1 h / 60 °C

1.2: 1 h / 50 °C

2.1: sodium hydroxide; water / ethanol / 5 h / Reflux

2.2: 20 °C / pH ~ 3

3.1: thionyl chloride / 2.5 h / Reflux

4.1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Cooling with ice

With thionyl chloride; water; ethyl iodide; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 13341-18-9
3-ethylpyridine-4-carbonitrile

: 1192021-71-8
N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / ethanol / 5 h / Reflux

1.2: 20 °C / pH ~ 3

2.1: thionyl chloride / 2.5 h / Reflux

3.1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Cooling with ice

With thionyl chloride; water; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 536-78-7,151103-56-9
3-ethylpyridine

: 1192021-71-8
N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dihydrogen peroxide; acetic acid / 9.5 h / 80 °C

2.1: ethyl iodide / 1 h / 60 °C

2.2: 1 h / 50 °C

3.1: sodium hydroxide; water / ethanol / 5 h / Reflux

3.2: 20 °C / pH ~ 3

4.1: thionyl chloride / 2.5 h / Reflux

5.1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Cooling with ice

With thionyl chloride; water; dihydrogen peroxide; ethyl iodide; acetic acid; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;