3-Ethylisonicotinonitrile

Base Information

• Chemical Name: 3-Ethylisonicotinonitrile
• CAS No.: 13341-18-9
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.165
• Mol file: 13341-18-9.mol

Synonyms:3-Ethylisonicotinonitrile;

Chemical Property of 3-Ethylisonicotinonitrile

Chemical Property:

• Boiling Point: 224 °C
• PKA: 2.22±0.18(Predicted)
• Flash Point: 90 °C
• PSA: 36.68000
• Density: 1.05 g/cm³
• LogP: 1.51568
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-?Ethylisonicotinonitr?ile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-?Ethylisonicotinonitr?ile acts as a reagent in the synthetic preparation of antitumor alkaloids (ellipticine and olivacine).

Technology Process of 3-Ethylisonicotinonitrile

There total 5 articles about 3-Ethylisonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium cyanide (773837-37-9) + 3-ethylpyridine N-oxide (14906-62-8) → 3-ethylpyridine-4-carbonitrile (13341-18-9)

Guidance literature:

3-ethylpyridine N-oxide; With ethyl iodide; at 60 ℃; for 1h;

sodium cyanide; In water; at 50 ℃; for 1h;

Reference yield:

sodium cyanide (773837-37-9) + 3-ethylpyridine N-oxide (14906-62-8) + ethyl iodide (75-03-6) → 3-ethylpyridine-4-carbonitrile (13341-18-9)

Guidance literature:

3-ethylpyridine N-oxide; ethyl iodide; at 60 ℃; for 1h;

sodium cyanide; In water; at 20 ℃;

Reference yield:

3-ethylpyridine (536-78-7,151103-56-9) → 3-ethylpyridine-4-carbonitrile (13341-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 15percent aq. H₂O₂ / acetic acid / 3.5 h / 100 °C

2: 1.) (CH₃)2SO₄ / 1.) 14 h, r.t., 2.) 50percent aq. EtOH, 14 h, r.t.

With dihydrogen peroxide; dimethyl sulfate; In acetic acid;

DOI:10.1002/jhet.5570270645

upstream raw materials:

3-ethylpyridine N-oxide

potassium cyanide

3-ethylpyridine

sodium cyanide

Downstream raw materials:

3-ethylpyridine-4-carboxylic acid

3-ethyl isonicotinic acid chloride

3-ethyl-4-pyridinemethanol

N-[4-chloro-2-hydroxy-5-(trifluoromethyl)phenyl]-3-ethyl isonicotinamide

Refernces

• 1、 -. "COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS". . . Retrieved 2011/04/25.
• 2、 -. "COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS". . . Retrieved 2011/05/06.