2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-2-propylcarbamoyl-ethyl)-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester

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Chemical Name:2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-2-propylcarbamoyl-ethyl)-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester
CAS No.:443764-19-0
Molecular Formula:C₄₅H₅₈N₆O₁₀
Molecular Weight:842.99
Hs Code.:

2-(2-benzyloxycarbonylamino-3-{3-[3-(2-<i>tert</i>-butoxycarbonylamino-2-propylcarbamoyl-ethyl)-1<i>H</i>-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid <i>tert</i>-butyl ester

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Chemical Property of 2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-2-propylcarbamoyl-ethyl)-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester

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Technology Process of 2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-2-propylcarbamoyl-ethyl)-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester

There total 10 articles about 2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-2-propylcarbamoyl-ethyl)-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51417-51-7
7-bromo-1H-indole

: 443764-19-0
2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-2-propylcarbamoyl-ethyl)-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tryptophane-synthetase; pyridoxal 5'-phosphate / 37 °C

2: N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxy-1H-benzotriazole

3: 80 percent / K₂CO₃ / [Pd(dppf)Cl₂]*CH₂Cl₂ / 1,2-dimethoxy-ethane; H₂O / 70 °C

4: N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxy-1H-benzotriazole

With tryptophane-synthetase; pyridoxal 5'-phosphate; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In 1,2-dimethoxyethane; water; 4: Suzuki cross-coupling reaction;
DOI:10.1002/1521-3773(20020301)41:5<780::AID-ANIE780>3.0.CO;2-V

Reference yield:

: 70-78-0
3-Iodo-L-tyrosine

: 443764-19-0
2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-2-propylcarbamoyl-ethyl)-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂

2: K₂CO₃

3: KOCOCH₃ / PdCl₂(dppf) / CH₂Cl₂

4: 80 percent / K₂CO₃ / [Pd(dppf)Cl₂]*CH₂Cl₂ / 1,2-dimethoxy-ethane; H₂O / 70 °C

5: N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxy-1H-benzotriazole

With thionyl chloride; potassium acetate; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In 1,2-dimethoxyethane; dichloromethane; water; 4: Miyauri-Suzuki reaction / 5: Suzuki cross-coupling reaction;
DOI:10.1002/1521-3773(20020301)41:5<780::AID-ANIE780>3.0.CO;2-V

Reference yield:

: 75816-19-2
(S)-7-bromo-tryptophan

: 443764-19-0
2-(2-benzyloxycarbonylamino-3-{3-[3-(2-tert-butoxycarbonylamino-2-propylcarbamoyl-ethyl)-1H-indol-7-yl]-4-methoxy-phenyl}-propionylamino)-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxy-1H-benzotriazole

2: 80 percent / K₂CO₃ / [Pd(dppf)Cl₂]*CH₂Cl₂ / 1,2-dimethoxy-ethane; H₂O / 70 °C

3: N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxy-1H-benzotriazole

With potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; In 1,2-dimethoxyethane; water; 3: Suzuki cross-coupling reaction;
DOI:10.1002/1521-3773(20020301)41:5<780::AID-ANIE780>3.0.CO;2-V