(4-tert-butoxycarbonylamino-5-hydroxy-6-{3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(4-tert-butoxycarbonylamino-5-hydroxy-6-{3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester
CAS No.:233690-80-7
Molecular Formula:C₃₈H₅₀N₆O₇
Molecular Weight:702.851
Hs Code.:

(4-<i>tert</i>-butoxycarbonylamino-5-hydroxy-6-{3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid <i>tert</i>-butyl ester

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Chemical Property of (4-tert-butoxycarbonylamino-5-hydroxy-6-{3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester

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Technology Process of (4-tert-butoxycarbonylamino-5-hydroxy-6-{3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester

There total 8 articles about (4-tert-butoxycarbonylamino-5-hydroxy-6-{3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 580-17-6
3-aminoquinoline

: 233690-80-7
(4-tert-butoxycarbonylamino-5-hydroxy-6-{3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. K₂CO₃ / methanol

1.2: EDAC / CH₂Cl₂

2.1: TFA / CH₂Cl₂

3.1: Et₃N / methanol

With potassium carbonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00006-9

Reference yield:

: 100564-78-1,108524-68-1,142926-43-0,82732-07-8
(2R)-(tert-butoxycarbonylamino)-4-phenylbutanoic acid

: 233690-80-7
(4-tert-butoxycarbonylamino-5-hydroxy-6-{3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: Et₃N / tetrahydrofuran

2.1: Et₃N / CH₂Cl₂

3.1: Burgess' reagent / tetrahydrofuran

3.2: CuBr₂; DBU; HMTA / CH₂Cl₂

4.1: aq. K₂CO₃ / methanol

4.2: EDAC / CH₂Cl₂

5.1: TFA / CH₂Cl₂

6.1: Et₃N / methanol

With Burgess Reagent; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00006-9

Reference yield:

: 233690-78-3
(4-tert-butoxycarbonylamino-hex-5-enyl)-carbamic acid tert-butyl ester

: 233690-80-7
(4-tert-butoxycarbonylamino-5-hydroxy-6-{3-phenyl-1-[4-(quinolin-3-ylcarbamoyl)-oxazol-2-yl]-propylamino}-hexyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: mCPBA / CH₂Cl₂

2: Et₃N / methanol

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00006-9