3-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-N-[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-N-methyl-propionamide

Base Information

• Chemical Name: 3-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-N-[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-N-methyl-propionamide
• CAS No.: 929088-03-9
• Molecular Formula: C₅₂H₅₉N₅O₁₃S
• Molecular Weight: 994.132

Synonyms:

Chemical Property of 3-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-N-[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-N-methyl-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-N-[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-N-methyl-propionamide

There total 12 articles about 3-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-N-[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-nitrophenyl)hexane-2,4-dione (192650-25-2) → 3-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-N-[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-N-methyl-propionamide (929088-03-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 65 percent / pTSA / toluene / Heating

2: 95 percent / H₂ / Pd/C / ethyl acetate

3: EDCI / CH₂Cl₂ / 0 °C

4: LiOH / tetrahydrofuran; H₂O

5: EDCI / CH₂Cl₂ / 0 °C

6: pTSA; water / acetone

With lithium hydroxide; water; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone; toluene;

DOI:10.1016/j.bmcl.2006.10.009

Reference yield:

C16H21NO6 (782475-33-6) → 3-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-N-[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-N-methyl-propionamide (929088-03-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / H₂ / Pd/C / ethyl acetate

2: EDCI / CH₂Cl₂ / 0 °C

3: LiOH / tetrahydrofuran; H₂O

4: EDCI / CH₂Cl₂ / 0 °C

5: pTSA; water / acetone

With lithium hydroxide; water; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone;

DOI:10.1016/j.bmcl.2006.10.009

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 3-[4-(2-{2-[2-(2-{2-[4-(3,5-dioxo-hexyl)-phenylcarbamoyl]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-N-[2'-(isoxazol-5-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-ylmethyl]-N-methyl-propionamide (929088-03-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 40 percent / LDA / hexamethylphosphoric acid triamide / -78 °C

2: 65 percent / pTSA / toluene / Heating

3: 95 percent / H₂ / Pd/C / ethyl acetate

4: EDCI / CH₂Cl₂ / 0 °C

5: LiOH / tetrahydrofuran; H₂O

6: EDCI / CH₂Cl₂ / 0 °C

7: pTSA; water / acetone

With lithium hydroxide; water; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; ethyl acetate; acetone; toluene;

DOI:10.1016/j.bmcl.2006.10.009

upstream raw materials:

6-(4-nitrophenyl)hexane-2,4-dione

4-{2-[2-(2-Methyl-[1,3]dioxolan-2-ylmethyl)-[1,3]dioxolan-2-yl]-ethyl}-phenylamine

C₁₆H₂₁NO₆

3-{2-[2-(2-{2-[4-(2-ethoxycarbonyl-ethyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionic acid

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