Nα-Z-Nα-Me-L-Val-L-Phe-OtBu

Base Information

Chemical Name:Nα-Z-Nα-Me-L-Val-L-Phe-OtBu
CAS No.:1313618-65-3
Molecular Formula:C₂₇H₃₆N₂O₅
Molecular Weight:468.593
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Nα-Z-Nα-Me-L-Val-L-Phe-OtBu

Chemical Property:

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Technology Process of Nα-Z-Nα-Me-L-Val-L-Phe-OtBu

There total 1 articles about Nα-Z-Nα-Me-L-Val-L-Phe-OtBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42417-65-2
Z-MeVal-OH

: 16874-17-2
L-phenylalanine tert-butyl ester

: 1313618-65-3
Nα-Z-Nα-Me-L-Val-L-Phe-OtBu

Guidance literature:: Z-MeVal-OH; L-phenylalanine tert-butyl ester; In dichloromethane; at 0 ℃; for 0.25h;

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/psc.1361

Reference yield:

: 1313618-65-3
Nα-Z-Nα-Me-L-Val-L-Phe-OtBu

: C₁₉H₃₀N₂O₃

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃;
DOI:10.1002/psc.1361

Reference yield:

: 1313618-65-3
Nα-Z-Nα-Me-L-Val-L-Phe-OtBu

: 1313619-14-5
C₂₉H₃₉N₅O₆S

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

2.1: dichloromethane / 0 °C

2.2: 0 - 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C

4.1: 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C

4.2: 3 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 72 h / 20 °C

With 2,4,6-trichlorobenzoyl chloride; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; 4.1: Yamaguchi esterification / 4.2: Yamaguchi esterification;
DOI:10.1002/psc.1361