8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile

Base Information

Chemical Name:8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile
CAS No.:1624604-77-8
Molecular Formula:C₂₁H₁₄F₆N₆O
Molecular Weight:480.372
Hs Code.:

8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile

Synonyms:

Suppliers and Price of 8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile

There total 11 articles about 8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 8-chloro-5-fluoro-1,7-naphthyridine-3-carbonitrile

: 1624606-64-9
(4S,6S)-4-(5-amino-2,3-difluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1624604-77-8
8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile

Guidance literature:

Reference yield:

: 760207-83-8
3-bromo-5-chloropyridine-2-carbonitrile

: 1624604-77-8
8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: triethanolamine / ethyl acetate; N,N-dimethyl-formamide; hexane

2: sodium methylate / methanol

3: toluene-4-sulfonic acid; dihydrogen peroxide; sodium carbonate / ethyl acetate; water; [⁽²⁾H₆]acetone; benzene

4: ethyl acetate; water; methanol

5: N,N-dimethyl-formamide

6: trichlorophosphate / acetonitrile

With triethanolamine; dihydrogen peroxide; sodium methylate; sodium carbonate; toluene-4-sulfonic acid; trichlorophosphate; In methanol; [⁽²⁾H₆]acetone; hexane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene;

Reference yield:

: 1600511-74-7
5-chloro-3-(2,2-dimethoxyethyl)picolinonitrile

: 1624604-77-8
8-((3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid; dihydrogen peroxide; sodium carbonate / ethyl acetate; water; [⁽²⁾H₆]acetone; benzene

2: ethyl acetate; water; acetonitrile

3: N,N-dimethyl-formamide

4: trichlorophosphate / acetonitrile

With dihydrogen peroxide; sodium carbonate; toluene-4-sulfonic acid; trichlorophosphate; In [⁽²⁾H₆]acetone; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene;