Technology Process of 3-tert-butyl 4-methyl (2S,4S)-2-tert-butyl-4-((R)-1-(benzyloxy)allyl)oxazolidine-3,4-dicarboxylate
There total 7 articles about 3-tert-butyl 4-methyl (2S,4S)-2-tert-butyl-4-((R)-1-(benzyloxy)allyl)oxazolidine-3,4-dicarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: chloro-trimethyl-silane; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 23 °C / Inert atmosphere
2: diethyl ether / Inert atmosphere
With
chloro-trimethyl-silane; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether;
1: Ireland-Claisen rearrangement;
DOI:10.1021/ol203300k
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / pentane / 72 h / 55 °C / Dean Stark conditions
2: sodium hydrogencarbonate / methanol / 18 h / 50 °C / Inert atmosphere
3: water; potassium hydroxide / methanol / 0 - 20 °C / Inert atmosphere
4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
5: chloro-trimethyl-silane; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 23 °C / Inert atmosphere
6: diethyl ether / Inert atmosphere
With
dmap; chloro-trimethyl-silane; water; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; pentane;
5: Ireland-Claisen rearrangement;
DOI:10.1021/ol203300k
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate / methanol / 18 h / 50 °C / Inert atmosphere
2: water; potassium hydroxide / methanol / 0 - 20 °C / Inert atmosphere
3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere
4: chloro-trimethyl-silane; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 23 °C / Inert atmosphere
5: diethyl ether / Inert atmosphere
With
dmap; chloro-trimethyl-silane; water; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
4: Ireland-Claisen rearrangement;
DOI:10.1021/ol203300k
