Technology Process of methyl 1-[4-methyl-3-(4-phenylpyrimidin-2-ylamino)phenyl]-1H-1,2,3-triazole-4-carboxylate
There total 6 articles about methyl 1-[4-methyl-3-(4-phenylpyrimidin-2-ylamino)phenyl]-1H-1,2,3-triazole-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
L-ascorbic acid sodium salt; copper(II) sulfate pentahydrate;
In
water; tert-butyl alcohol;
at 50 ℃;
for 5h;
DOI:10.1002/cmdc.201100304
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere; Reflux
2.1: iron(III) chloride; hydrazine hydrate / methanol / 4 h / 100 °C / Reflux
3.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C
3.2: 3 h / 0 - 20 °C
4.1: L-ascorbic acid sodium salt; copper(II) sulfate pentahydrate / water; tert-butyl alcohol / 5 h / 50 °C
With
iron(III) chloride; copper(l) iodide; L-ascorbic acid sodium salt; sulfuric acid; copper(II) sulfate pentahydrate; potassium carbonate; hydrazine hydrate; N,N`-dimethylethylenediamine; sodium nitrite;
In
1,4-dioxane; methanol; water; tert-butyl alcohol;
1.1: Ullmann reaction;
DOI:10.1002/cmdc.201100304
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C
1.2: 3 h / 0 - 20 °C
2.1: L-ascorbic acid sodium salt; copper(II) sulfate pentahydrate / water; tert-butyl alcohol / 5 h / 50 °C
With
L-ascorbic acid sodium salt; sulfuric acid; copper(II) sulfate pentahydrate; sodium nitrite;
In
water; tert-butyl alcohol;
DOI:10.1002/cmdc.201100304
