Technology Process of 5-cyclohexyl-4-methyl-N,N-diphenylpentanamide
There total 4 articles about 5-cyclohexyl-4-methyl-N,N-diphenylpentanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
cyclohexylmethyl-9-BBN;
With
potassium tert-butylate;
In
hexan-1-ol;
for 0.5h;
Inert atmosphere;
Sealed vial;
With
nickel(II) bromide 2-methoxyethyl ether complex; (S,S)-N,N'-dimethyl-1,2-diphenylethane-1,2-diamine;
In
diethyl ether; hexane; hexan-1-ol;
for 0.5h;
Inert atmosphere;
Sealed vial;
4-chloro-N,N-diphenylpentanamide;
In
diethyl ether; hexane; hexan-1-ol;
at 20 ℃;
for 24h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Sealed vial;
DOI:10.1021/ja2079515
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: benzene / 6 h / Inert atmosphere; Reflux
2.1: potassium tert-butylate / hexan-1-ol / 0.5 h / Inert atmosphere; Sealed vial
2.2: 0.5 h / Inert atmosphere; Sealed vial
2.3: 24 h / 20 °C / Inert atmosphere; Sealed vial
With
potassium tert-butylate;
In
hexan-1-ol; benzene;
2.1: Suzuki cross-coupling / 2.2: Suzuki cross-coupling / 2.3: Suzuki cross-coupling;
DOI:10.1021/ja2079515
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethyl ether / 1.5 h / 40 °C / Inert atmosphere; Sealed vial
2.1: potassium tert-butylate / hexan-1-ol / 0.5 h / Inert atmosphere; Sealed vial
2.2: 0.5 h / Inert atmosphere; Sealed vial
2.3: 24 h / 20 °C / Inert atmosphere; Sealed vial
With
potassium tert-butylate;
In
diethyl ether; hexan-1-ol;
2.1: Suzuki cross-coupling / 2.2: Suzuki cross-coupling / 2.3: Suzuki cross-coupling;
DOI:10.1021/ja2079515
