63480-12-6

Basic information

• Product Name: 4-CHLORO-PENTANOYL CHLORIDE
• Synonyms: 4-CHLORO-PENTANOYL CHLORIDE;4-Chlorovaleroyl Chloride (4-Chloropentanoyl Chloride);Pentanoyl chloride,4-chloro-;_x005f\r4-Chloropentanoyl Chloride
• CAS NO: 63480-12-6
• Molecular Formula: C₅H₈Cl₂O
• Molecular Weight: 155.02
• Mol File: 63480-12-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 186.7±13.0 °C(Predicted)
• Appearance: /
• Density: 1.180±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform, Ethyl Acetate
• Stability: Air and Moisture Sensitive
• CAS DataBase Reference: 4-CHLORO-PENTANOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-PENTANOYL CHLORIDE(63480-12-6)
• EPA Substance Registry System: 4-CHLORO-PENTANOYL CHLORIDE(63480-12-6)

Safety Data

• Hazardous Substances Data: 63480-12-6(Hazardous Substances Data)

Usage

Uses

4-Chloropentanoyl Chloride is an intermediate used to prepare Tachykinin Antagonists. It is also used in the synthesis of aminobenzo[a]quinolizines as long-lasting dipeptidyl peptidase IV inhibitors.

Upstream product

• 638-29-9 n-valeryl chloride 
• 7782-50-5 chlorine 
• 71-43-2 benzene 

Downstream Products

• 53102-14-0 3-chlorocyclopent-2-en-1-one 
• 1334228-74-8 4-chloro-N,N-diphenylpentanamide 
• 1334228-87-3 5-cyclohexyl-4-methyl-N,N-diphenylpentanamide 
• 1338582-47-0 4-Chloro-N'-(diphenylmethylene)pentane hydrazide 
• 4831-02-1 4-chloro-1-phenylpentan-1-one 

Relevant articles and documents

Free Radical Substitution. Part 37. The Effect of Solvent on the Atomic Chlorination of 1-Substituted Butanes and Related Compounds

Experimental results reported in this paper show that the relative selectivity of atomic chlorination of 1-substituted butanes and related compounds is greatly influenced by the phase and by solvents.Solvents can be divided into three classes: (a) inert, (b) solvents which decrease the selectivity, and (c) solvents which increase the selectivity.The second group solvate the transition state and the third group solvate the chlorine atoms.

Chlorination of Carboxylic Acid Derivatives. VIII. Liquid Phase Chlorination of the Aliphatic C5-Carboxylic Acids and Their Chlorides, Methyl Esters and Chloromethyl Esters with Chlorine

The chlorination of pentanoic, 3-methylbutanoic, 2-methylbutanoic and 2,2-dimethylpropanoic acids and their derivatives with chlorine in the liquid phase have been investigated.The monochloro products formed were determined by gas-liquid chromatography (GLC) and gas-liquid chromatography-mass spectrometry (GLC-MS) as their esters through the comparison with authentic samples.The deactivation of position 2 decreases in the order COCl > CO2H > CO2CH2Cl > CO2CH3, the effect of the COCl-group in pentanoic acid derivatives being 4.3 times stronger than that of the CO2CH3-group.The deactivation is smallest in 2-methylbutanoic acid derivatives owing to the electron-donating methyl group.The EI mass spectra of the methyl and chloromethyl esters have been studied in detail.