(3aR,4S,6R,6aS)-6-[7-Amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol

Base Information

Chemical Name:(3aR,4S,6R,6aS)-6-[7-Amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol
CAS No.:274693-22-0
Molecular Formula:C₁₅H₂₂N₆O₃S
Molecular Weight:366.444
Hs Code.:
Mol file:274693-22-0.mol

Synonyms:

Suppliers and Price of (3aR,4S,6R,6aS)-6-[7-Amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aR,4S,6R,6aS)-6-[7-Amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol

Chemical Property:

Boiling Point:657.3±65.0 °C(Predicted)
PKA:13.56±0.60(Predicted)
Density:1.71±0.1 g/cm3 (20 oC 760 Torr)

Purity/Quality:: 98% Min ^*data from raw suppliers

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Technology Process of (3aR,4S,6R,6aS)-6-[7-Amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol

There total 4 articles about (3aR,4S,6R,6aS)-6-[7-Amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 220241-61-2
(3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

: 274693-22-0
(3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

Guidance literature:: With ammonia; In tetrahydrofuran; at 20 ℃; for 1h; Sealed tube;
DOI:10.1016/j.ejmech.2020.112767

Reference yield:

: 145783-15-9
4,6-dichloro-2-(propylsulfanyl)-5-pyrimidinamine

: 274693-22-0
(3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 110 °C / Sealed tube

2: acetic acid; sodium nitrite / 0 - 20 °C

3: ammonia / tetrahydrofuran / 1 h / 20 °C / Sealed tube

With ammonia; acetic acid; triethylamine; sodium nitrite; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2020.112767

Reference yield:

: 220241-60-1
(3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

: 274693-22-0
(3aR,4S,6R,6aS)-6-(7-amino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium nitrite / 0 - 20 °C

2: ammonia / tetrahydrofuran / 1 h / 20 °C / Sealed tube

With ammonia; acetic acid; sodium nitrite; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2020.112767