Technology Process of 7-(iodopropyl)-N,N-dibenzyloxycarbonyl-1-(aminopropyl)-1,7-carborane
There total 1 articles about 7-(iodopropyl)-N,N-dibenzyloxycarbonyl-1-(aminopropyl)-1,7-carborane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate;
In
dichloromethane;
byproducts: Bu4NI; (N2); using Schlenk techniques; addn. of soln. of dibenzyl iminodicarboxylate in CH2Cl2 to stirred soln. of Bu4NHSO4 and 2 M NaOH in CH2Cl2; stirring for 30 min; addn. dropwise of soln. of 1,7-bis(iodopropyl)-1,7-carborane in CH2Cl2, reflux for 6 h; extn. of aq. layer with CH2Cl2, concn. in vac. of combined org. extracts, stirring with Et2O for 30 min, pptn., vac. filtration, drying of filtrate over anhyd. Na2SO4, concn. in vac., flash chromy. on SiO2, eluting with 25% Et2O in hexane, elem. anal.;
DOI:10.1039/b408801h
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
(N2); using Schlenk techniques; heating of soln. of di-tert-butyl-iminodicarboxylate (1 equiv.), K2CO3, IC3H6CB10H10CC3H6N(COOCH2Ph)2 in DMF at 60°C for 24 h; concn. to dryness in vac., dissolving in CH2Cl2 and H2O, extn. of aq. soln. with another portion of CH2Cl2; washing of combined org. layers withH2O, brine; drying over anhyd. MgSO4, concn., chromy. on SiO2 (10-50% E t2O in n-C6H14); as oil; elem. anal.;
DOI:10.1039/b408801h
