5-((((1,3-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)methyl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Base Information

Chemical Name:5-((((1,3-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)methyl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol
CAS No.:1416265-33-2
Molecular Formula:C₁₇H₂₀FN₅S
Molecular Weight:345.444
Hs Code.:

Synonyms:

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Chemical Property of 5-((((1,3-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)methyl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

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Technology Process of 5-((((1,3-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)methyl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

There total 6 articles about 5-((((1,3-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)methyl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2521-99-5
2-(4-fluorophenylamino)acetic acid ethyl ester

: 1416265-33-2
5-((((1,3-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)methyl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 20 °C

2.1: potassium ethoxide / benzene / 0 °C

2.2: 2 h / 60 °C

3.1: water; lithium hydroxide / 1,4-dioxane; methanol / 50 °C

4.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 40 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

6.1: sodium cyanoborohydride; acetic acid / N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; potassium ethoxide; water; sodium cyanoborohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; benzene;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1416265-33-2
5-((((1,3-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)methyl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium acetate / ethanol / 2 h / 80 °C

2.1: tetrahydrofuran / 20 °C

3.1: potassium ethoxide / benzene / 0 °C

3.2: 2 h / 60 °C

4.1: water; lithium hydroxide / 1,4-dioxane; methanol / 50 °C

5.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 40 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

7.1: sodium cyanoborohydride; acetic acid / N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; potassium ethoxide; water; sodium acetate; sodium cyanoborohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; benzene;

Reference yield:

: 1416265-19-4
1-(4-fluorophenyl)-2-mercapto-N-methoxy-N-methyl-1H-imidazole-5-carboxamide

: 1416265-33-2
5-((((1,3-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)methyl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C

2: sodium cyanoborohydride; acetic acid / N,N-dimethyl-formamide / 1 h / 20 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;