Synonyms:Acetylchloride, [2,4-bis(1-methylbutyl)phenoxy]- (9CI)
99% *data from raw suppliers
There total 1 articles about [2,4-Bis(1-methylbutyl)phenoxy]acetic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
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The research focuses on the copper-catalyzed multicomponent reactions (MCRs) of terminal alkynes, acid chlorides, and carbodiimides to synthesize functionalized propiolamidine derivatives. The study explores the efficiency of various bases and solvents to optimize the reaction conditions. The optimal catalytic system was found to be a combination of CuI, triethylamine (TEA), and acetonitrile (CH3CN), yielding the desired products in good to excellent yields. The experiments involved a suspension of carbodiimide and acid chloride, followed by the addition of anhydrous acetonitrile, TEA, CuI, and alkyne at room temperature under a nitrogen atmosphere. The reaction mixture was stirred, then extracted with CH2Cl2, washed with saturated NaHCO3 solution and water, dried over anhydrous MgSO4, and evaporated under vacuum. The residue was purified using silica gel column chromatography with petroleum ether/ethyl acetate as the eluent. The analysis of the reaction products was based on isolated yields, which were calculated based on the amount of N,N’-dialkylcarbodiimides used.
The research focuses on the development of an efficient one-pot synthesis method for 2-substituted 4-aryl-4,5-dihydro-3,1-benzoxazepine derivatives, which are compounds of potential biological importance due to their structure being a homolog of the 4H-3,1-benzoxazine skeleton found in many biologically active compounds. The experiments involve the reaction of 2-(2-aminophenyl)ethanols with acid chlorides in the presence of excess Et3N in THF at room temperature to form N-acylated intermediates, which are then dehydrated with POCl3 to yield the desired benzoxazepine derivatives. The reactants include 2-(2-aminophenyl)ethanols, acid chlorides, Et3N, THF, and POCl3. The analyses used to characterize the products encompass techniques such as infrared (IR) spectroscopy, proton and carbon-13 nuclear magnetic resonance (1H-NMR and 13C-NMR), mass spectrometry (MS), and elemental analysis, which are detailed in the experimental part of the article.
The study focuses on the structure-activity relationships of novel anti-malarial agents, specifically N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2furyl]acrylic acid amides. The researchers developed a lead compound, benzophenone 4g, which was modified by replacing the tolylacetyl residue at the 2-amino group with various acyl residues to determine their influence on anti-malarial activity. The chemicals used included 2-amino-5-nitrobenzophenone, acid chlorides for acylation, SnCl2?2H2O for reduction, and 3-[5-(4-nitrophenyl)-2-furyl]acrylic acid chloride for further acylation. The purpose of these chemicals was to synthesize and test a series of compounds to identify the optimal acyl residue structure for high anti-malarial activity, with the aim of overcoming drug resistance in Plasmodium falciparum, the causative agent of malaria. The study found that a phenylacetic acid substructure substituted in its para-position with methyl or similar-sized substituents was essential for high activity, with the trifluoromethyl-substituted derivative showing the most potent activity.
The study explores the reactivity and synthetic utility of triflones (CF3SO2C), which are compounds containing the trifluoromethanesulfonyl group (CF3SO2-). This group is known for being a strong electron-withdrawing group, making triflones potentially valuable in synthesis. The research is divided into three parts: First, it examines the triflinate anion (CF3SO2-) as both a nucleophile and a leaving group, demonstrating its ability to form alkyl triflones through nucleophilic substitution of primary halides and its reactivity with acid chlorides and alkyl halides. Second, the study investigates triflone α-carbanions, showing that they can undergo monoalkylation and conjugate addition reactions, as well as participate in the Mannich reaction. Finally, the study looks at additions to vinyl triflones, finding that they can react with various nucleophiles and undergo cyclopropane cyclizations. The study highlights that triflones can be readily removed from carbonyl groups through various elimination reactions and that their 1,2- and 1,3-eliminations are more facile than those of other sulfones, offering significant synthetic advantages.
The research focuses on the synthesis and biological evaluation of two recently isolated flavones, 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone (3a) and 5-carboethoxymethyl-4,7-dihydroxyflavone (3b), along with their derivatives (3c–t). The main objective was to assess the antimicrobial, antioxidant, and anticancer activities of these compounds. The synthesis was achieved through a series of reactions starting from methyl curvulinate (4), using two primary methods: the Baker-Venkatraman rearrangement and the chalcone route. Various reagents such as acid chloride, sodium hydride, and ferric chloride were employed, and the synthesized compounds were purified and characterized using techniques like column chromatography, NMR, and mass spectrometry. The biological activities were evaluated through different in vitro assays, including the modified microtiter broth dilution method for antibacterial activity, the well diffusion method for antifungal activity, and various antioxidant potential tests like DPPH radical scavenging, superoxide radical scavenging, lipid peroxidation inhibition, and erythrocyte hemolysis inhibition. The synthesized compounds were compared with standard drugs like neomycin and luteolin for their activity.
This research presents the synthesis and evaluation of novel prodrugs of naproxen, a nonsteroidal anti-inflammatory drug (NSAID), aimed at enhancing its pharmaceutical and pharmacokinetic properties while reducing gastrointestinal (GI) toxicity. The study involved the reaction of naproxen with thionyl chloride to form an acid chloride, which was then reacted with glucose to produce glucosyl naproxen. This was followed by acetylation and reaction with various amino acids to yield the prodrugs. The synthesized prodrugs were evaluated for analgesic and anti-inflammatory activities and assessed for GI toxicity. The results indicated that the prodrugs maintained the therapeutic activities of naproxen while significantly reducing GI irritation. Key chemicals used in the synthesis process included naproxen, thionyl chloride, glucose, pyridine, acetic anhydride, and different amino acids such as glycine, valine, alanine, cysteine, and others. The synthesized compounds were characterized using IR, NMR, and MS spectral methods. The study concluded that these novel prodrugs could be potentially useful naproxen derivatives for oral administration due to their stability in aqueous solutions, retention of analgesic and anti-inflammatory activity, and notably reduced GI irritation.
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